Genome expression and maintenance
The overall goal of our lab is to understand the mechanisms of eukaryotic genome expression and maintenance. We focus on the question, how the different steps of gene expression, mainly transcription and nuclear mRNP formation, are interconnected providing efficiency and accuracy to this fundamental cellular process. Furthermore, we investigate the molecular mechanism of enzymes and enzyme complexes that cut, modify and repair DNA. To achieve our goals, we employ a multitude of modern biochemical, genetical, molecular biological as well as computational techniques.