ausgewählte Publikationen

Seiz J.R., Klinke J., Scharlibbe L., Lohfink; d., Heipel M., Ungefroren H., Giehl K., Menke A. Different signaling and functionality of Rac1 and Rac1b in the progression of lung adenocarcinoma. Biol. Chem. 2020 401(4):517-531

Meinohl C., Barnard S.J. Fritz-Wolf K., Unger M., Porr A., Heipel M., Wirth S., Madlung J., Nordheim A., Menke A., Becker K., Giehl K. Galectin-8 binds to the farnesylated C-terminus of K-Ras4B and modifes Ras/ERK signaling and migration in pancreatic and lung carcinoma cells. Cancers (Basel). 2019 Dec 20;12(1)

Fichtner D., Lorenz B., Engin S., Deichmann C., Oelkers M., Janshoff A., Menke A.,Wedlich D., Franz C.M. Covalent and density-controlled surface immobilization of E-cadherin for adhesion force spectroscopy. PLoS One, 9:e93123, 2014.

Menke A., Giehl K. Regulation of adherens junctions by Rho GTPases and p120-catenin. Arch. Biochem. Biophys., Special issue: Cell-Cell Communication in Development and Disease, 524:48-55, 2012.

Nuessle J., Giehl K., Herzog R., Stracke S., Menke A. TGFβ1 suppresses vascular smooth muscle cell motility by expression of N-cadherin. Biological Chemistry 392:461-75, 2011.

Jesse S., Koenig A., Ellenrieder V., Menke A. Lef-1 affects different target genes by using distinct splice variants in pancreatic cancer cells. Int. J. Cancer 126:1109-1120, 2010.

Beilke S, Oswald F, Genze F, Wirth T, Adler G, Wagner M., The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice. Oncogene 29:4058-67, 2010.

Hage B., Meinel K., Baum I., Menke A, and Giehl K. Rac1 activation inhibits E-Cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells. Cell Communication and Signaling, 7:23, 2009.

Dietrich K.-A., Schwarz R., Liska M., Graß S., Menke A., Meister M., Kierschke G., Längle C., Genze F., Giehl K. Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC which differs from RhoA in its localization and activity. Biological Chemistry 390:1063-77, 2009.

Schreiber S.C., Giehl K., Kastilan C., Hasel C., Mühlenhoff M., Adler G., Wedlich D., Menke A. Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells. Gastroenterology 134:1555-1566, 2008.

Giehl K., Menke A. Microenvironmental regulation of E-cadherin-mediated adherens junctions. Frontier in Bioscience 13:3975-3985, 2008.

Imamichi Y., Menke A. The focal adhesion kinase in tumour environment-induced epithelial to mesenchymal transition. Cell, Tissues and Organs, 185:180-190, 2007.

König A., Müller C., Hasel C., Adler G., Menke A. Collagen type I induces disruption of E-cadherin mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells. Cancer Res. 66:4662-4671, 2006.

Vogelmann R., Nguyen-tat M.D., Giehl K., Adler G., Wedlich D., Menke A. TGFβ-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN. J. Cell Sci., 118:4901-4912, 2005.

Imamichi Y., Waidmann O., Hein R., Eleftheriou P., Giehl K., Menke A. TGFβ-induced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4. Biol. Chem., 386:225-236, 2005.

Seidel B., Braeg S., Adler G., Wedlich D., Menke A. E- and N-cadherin differ with respect to their associated p120ctn-isoforms and their ability to suppress invasive growth in pancreatic cancer cells. Oncogene, 23:5532-5542, 2004.

Veit C., Genze F., Menke A., Hoeffert S., Gress T.M., Gierschik P., and Giehl K. Activation of PI 3-kinase and ERK is required for GDNF-induced migration and invasion of pancreatic carcinoma cells. Cancer Res. 64:5291-5300, 2004. 

Giehl K., Fensterer H., Buchholz M., Ellenrieder V., Buck A., Kestler H.A., Adler G., Gierschik P., and Gress T.M. Expression profiling of the influence of Ras mutants on the TGFβ-induced phenotype of pancreatic cancer cells. Genes Chromosomes Cancer 39:224-235, 2004.

Giehl K., Skripczynski B., Mansard A., Menke A., and Gierschik P. Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration. Oncogene 19: 2930-2942, 2000.     

Menke A., Jockusch H. Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse. Nature 349: 69-71, 1991.