Inhaltspezifische Aktionen

Microbial Community

Microbial Community

The human body including gut, nose, lung, skin, etc., host numerous microbial species and complex microbial ecosystems that play a fundamental role in the host's well-being. In nature, most microbes do not exist in isolation but rather form part of dynamic and ever-changing microbial consortia. These microbes continuously alter their surroundings, benefiting or disadvantaging other organisms within the community. Such interactions shape community composition and structure while also influencing the onset or progression of diseases.
Metabolic exchange factors can drive morphological and developmental processes and impact the survival of individual microbes. Predicting these exchanges provides valuable insights into whether interacting partners promote or inhibit each other's growth, regardless of the specific mechanistic details of the species involved.

Materials

 

Recommended Literature 

Competitive and cooperative metabolic interactions in bacterial communities, Freilich et al. (2011)

OptCom: A Multi-Level Optimization Framework for the Metabolic Modeling and Analysis of Microbial Communities, Zomorrodi et al. (2012)

Lotka-Volterra pairwise modeling fails to capture diverse pairwise microbial interactions, Momeni et al. (2017)


NCMW: A Python Package to Analyze Metabolic Interactions in the Nasal Microbiome, Glöckler M., Drägler A., Mostolizadeh R., (2022)

Towards the human nasal microbiome: Simulating D. pigrum and S. aureus, Mostolizadeh et al. (2022)

Hierarchical modelling of microbial communities, Glöckler M., Drägler A., Mostolizadeh R. (2023)

Tools

NCMW

MICOM