Inhaltspezifische Aktionen

2000-2004

 

  • Started work at Purdue in August, 2000 as visiting graduate research assistant

Environmental applications of membrane introduction mass spectrometry (MIMS) and electrospray/atmospheric pressure chemical ionization mass spectrometry. Took part in the development of novel MIMS systems and developed novel methodology for the environmental detection of organic chloroamines.


  • 2001 finishing PhD in Hungary and returning to Purdue in 2002

Mainly involved in the clustering behavior of natural amino acids. The aim was to find the origins of homochirality on Earth in the reactions of homochiral and heterochiral amino acid clusters. Result: got acquainted with various spray ionization techniques and started own research project on the development of new atmospheric pressure ionization techniques.

 
Discovered various ways of chiral transmission, i.e. how homochiral amino acids can influence the formation of other homochiral amino acids and carbohydrates.


  • Started as a post doctoral research assistant at Purdue University in January 2003.

Project: “Preparation of protein microarrays by soft landing of mass-selected macromolecular ions”. Aim was the development of preparative mass spectrometry, for the purification of proteins. Core idea: ionosation of proteins by electrospray and separation of ions based on their different mass-to-charge ratio, using mass spectrometry. Separated ions were deposited onto a surface instead of destructive detection. Involvement covered everything bar the design and construction of mass analyzer. Led the subgroup responsible for the preparation of samples, for the construction of the ion source, for preparing surfaces for soft landing and the analysis of soft-landed samples.

Invention of electrosonic-spray ionization, a new spray technique capable of ionizing proteins without any serious unfolding of protein molecules. Development of surface analysis techniques led to the invention of desorption electrospray ionization and other new desorption ionization methods generally termed as direct ionization mass spectrometry. Both my inventions got commercialized through Inproteo LLC and Prosolia Inc. Electrosonic spray technique licensed out to Thermo Fisher, a leading mass spectrometry company. Desorption electrospray directly commercialized by Prosolia.