Prof. Dr. Zoltán Takáts

Date of birth:

22.10.1974

Place of birth:

Budapest, Hungary

Education and Employment:

1993-1998     

Studies in Chemistry

Eötvös Loránd University, Budapest, Hungary

1998   

Diploma in Chemistry

1998-2002     

PhD in Chemistry

Eötvös Loránd University, Budapest, Hungary

PhD thesis: „Investigation of the environmental fate of xenobiotics by modern mass spectrometric techniques”

1998-2000     

Chemical Research Centre, Hungarian Academy of Sciences

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Graduate research assistant

2000-2004     

Purdue University, Department of Chemistry, Aston Laboratories for Mass Spectrometry

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2005               

Chemical Research Centre, Hungarian Academy of Sciences

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2006-2009

Semmelweis University, Cell Screen Applied Research Center

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2006               

Semmelweis University, 1^st Department of Pediatrics

Organisation of the nationwide screening program for the population-level screening of inborn errors of metabolism.

Since 2008

Justus Liebig Universität Giessen, Institut für Anorganische und Analytische Chemie, Giessen, Germany

Publications:

1.

Balog, J.; Szaniszlo, T.; Schaefer, K. C.; Denes, J.; Lopata, A.; Godorhazy, L.; Szalay, D.; Balogh, L.; Sasi-Szabo, L.; Toth M.; Takats, Z., Identification of Biological Tissues by Rapid Evaporative Ionization Mass Spectrometry, Analytical Chemistry, DOI: 10.1021/ac101283x, Publication Date (Web): August 3, 2010.

2.

Gerbig, S.; Takats, Z., Analysis of triglycerides in food items by desorption electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry 2010, 24, (15), 2186-2192.

3.

Rompp, A.; Guenther, S.; Schober, Y.; Schulz, O.; Takats, Z.; Kummer, W.; Spengler, B., Histology by Mass Spectrometry: Label-Free Tissue Characterization Obtained from High-Accuracy Bioanalytical Imaging. Angewandte Chemie-International Edition 2010, 49, (22), 3834-3838.

4.

Katona, M.; Kiss, K.; Angyal, V.; Kucsma, N.; Sarkadi, B.; Takats, Z.; Szakacs, G., A mass spectrometry based functional assay for the quantitative assessment of ABC transporter activity. Rapid Communications in Mass Spectrometry 2009, 23, (21), 3372-3376.

5.

Schafer, K. C.; Denes, J.; Albrecht, K.; Szaniszlo, T.; Balog, J.; Skoumal, R.; Katona, M.; Toth, M.; Balogh, L.; Takats, Z., In Vivo, In Situ Tissue Analysis Using Rapid Evaporative Ionization Mass Spectrometry. Angewandte Chemie-International Edition 2009, 48, (44), 8240-8242.

6.

Hegedus, C.; Ozvegy-Laczka, C.; Apati, A.; Magocsi, M.; Nemet, K.; Orfi, L.; Keri, G.; Katona, M.; Takats, Z.; Varadi, A.; Szakacs, G.; Sarkadi, B., Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. British Journal of Pharmacology 2009, 158, (4), 1153-1164.

7.

Denes, J.; Katona, M.; Hosszu, A.; Czuczy, N.; Takats, Z., Analysis of Biological Fluids by Direct Combination of Solid Phase Extraction and Desorption Electrospray Ionization Mass Spectrometry. Analytical Chemistry 2009, 81, (4), 1669-1675.

8.

Taban, L. M.; van der Burgt, Y. E. M.; Duursma, M.; Takats, Z.; Seynen, M.; Konijnenburg, M.; Vijftigschild, A.; Attema, I.; Heeren, R. M. A., A novel workflow control system for Fourier transform ion cyclotron resonance mass spectrometry allows for unique on-the-fly data-dependent decisions. Rapid Communications in Mass Spectrometry 2008, 22, (8), 1245-1256.

9.

Takats, Z.; Kobliha, V.; Sevcik, K.; Novak, P.; Kruppa, G.; Lemr, K.; Havlicek, V., Characterization of DESI-FTICR mass spectrometry - from ECD to accurate mass tissue analysis. Journal of Mass Spectrometry 2008, 43, (2), 196-203.

10.

Vargha, M.; Takats, Z.; Konopka, A.; Nakatsu, C. H., Optimization of MALDI-TOF MS for strain level differentiation of Arthrobacter isolates. Journal of Microbiological Methods 2006, 66, (3), 399-409.

11.

Cooks, R. G.; Wiseman, J.; Venter, A.; Talaty, N.; Niefliu, M.; Takats, Z., Metabolomics, tissue analysis and pharmaceutical analysis in the ambient environment. Abstracts of Papers of the American Chemical Society 2006, 231, 323-ANYL.

12.

Cooks, R. G.; Ouyang, Z.; Takats, Z.; Wiseman, J. M., Ambient mass spectrometry. Science 2006, 311, (5767), 1566-1570.

13.

Myung, S.; Wiseman, J. M.; Valentine, S. J.; Takats, Z.; Cooks, R. G.; Clemmer, D. E., Coupling desorption electrospray ionization with ion mobility/mass spectrometry for analysis of protein structure: Evidence for desorption of folded and denatured states. Journal of Physical Chemistry B 2006, 110, (10), 5045-5051.

14.

Talaty, N.; Takats, Z.; Cooks, R. G., Rapid in situ detection of alkaloids in plant tissue under ambient conditions using desorption electrospray ionization. Analyst 2005, 130, (12), 1624-1633.

15.      

Wiseman, J. M.; Takats, Z.; Gologan, B.; Davisson, V. J.; Cooks, R. G., Direct characterization of enzyme-substrate complexes by using electrosonic spray ionization mass spectrometry. Angewandte Chemie-International Edition 2005, 44, (6), 913-916.

16.

Wiseman, J. M.; Puolitaival, S. M.; Takats, Z.; Cooks, R. G.; Caprioli, R. M., Mass spectrometric profiling of intact biological tissue by using desorption electrospray ionization. Angewandte Chemie-International Edition 2005, 44, (43), 7094-7097.

17.

Chen, H. W.; Talaty, N. N.; Takats, Z.; Cooks, R. G., Desorption electrospray ionization mass spectrometry for high-throughput analysis of pharmaceutical samples in the ambient environment. Analytical Chemistry 2005, 77, (21), 6915-6927.

18.      

Cotte-Rodriguez, I.; Takats, Z.; Talaty, N.; Chen, H. W.; Cooks, R. G., Desorption electrospray ionization of explosives on surfaces: Sensitivity and selectivity enhancement by reactive desorption electrospray ionization. Analytical Chemistry 2005, 77, (21), 6755-6764.

19.

Takats, Z.; Wiseman, J. M.; Cooks, R. G., Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology. Journal of Mass Spectrometry 2005, 40, (10), 1261-1275.

20.      

Vargha, M.; Takats, Z.; Marialigeti, K., Degradation of atrazine in a laboratory scale model system with Danube river sediment. Water Research 2005, 39, (8), 1560-1568.

21.

Takats, Z.; Cotte-Rodriguez, I.; Talaty, N.; Chen, H. W.; Cooks, R. G., Direct, trace level detection of explosives on ambient surfaces by desorption electrospray ionization mass spectrometry. Chemical Communications 2005, (15), 1950-1952.

22.

Misharin, A. S.; Laughlin, B. C.; Vilkov, A.; Takats, Z.; Zheng, O. Y.; Cooks, R. G., High-throughput mass spectrometer using atmospheric pressure ionization and a cylindrical ion trap array. Analytical Chemistry 2005, 77, (2), 459-470.

23.

Gologan, B.; Takats, Z.; Alvarez, J.; Wiseman, J. M.; Talaty, N.; Ouyang, Z.; Cooks, R. G., Ion soft-landing into liquids: Protein identification, separation, and purification with retention of biological activity. Journal of the American Society for Mass Spectrometry 2004, 15, (12), 1874-1884.

24.

Nagy, K.; Pollreisz, F.; Takats, Z.; Vekey, K., Atmospheric pressure chemical ionization mass spectrometry of aldehydes in biological matrices. Rapid Communications in Mass Spectrometry 2004, 18, (20), 2473-2478.

25.      

Blake, T. A.; Zheng, O. Y.; Wiseman, J. M.; Takats, Z.; Guymon, A. J.; Kothari, S.; Cooks, R. G., Preparative linear ion trap mass spectrometer for separation and collection of purified proteins and peptides in arrays using ion soft landing. Analytical Chemistry 2004, 76, (21), 6293-6305.

26.      

Takats, Z.; Wiseman, J. M.; Gologan, B.; Cooks, R. G., Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 2004, 306, (5695), 471-473.

27.      

Nanita, S. C.; Takats, Z.; Cooks, R. G., Chiral enrichment of serine via formation, dissociation, and soft-landing of octameric cluster ions. Journal of the American Society for Mass Spectrometry 2004, 15, (9), 1360-1365.

28.      

Takats, Z.; Wiseman, J. M.; Gologan, B.; Cooks, R. G., Electrosonic spray ionization. A gentle technique for generating folded proteins and protein complexes in the gas phase and for studying ion - Molecule reactions at atmospheric pressure. Analytical Chemistry 2004, 76, (14), 4050-4058.

29.      

Cooks, R. G.; Ouyang, Z.; Takats, Z.; Gologan, B.; Blake, T. M.; Davisson, V. J., Ion soft land as a preparative method: Protein microarrays generated by mass spectrometry. Abstracts of Papers of the American Chemical Society 2004, 227, 178-PHYS.

30.      

Takats, Z.; Cooks, R. G., Thermal formation of serine octamer ions. Chemical Communications 2004, (4), 444-445.

31.      

Takats, Z.; Nanita, S. C.; Cooks, R. G., Serine octamer reactions: Indicators of prebiotic relevance. Angewandte Chemie-International Edition 2003, 42, (30), 3521-3523.

32.      

Schlosser, G.; Takats, Z.; Vekey, K., Formation of solvated ions in the atmospheric interface of an electrospray ionization triple-quadrupole mass spectrometer. Journal of Mass Spectrometry 2003, 38, (12), 1245-1251.

33.      

Nagy, K.; Takats, Z.; Pollreisz, F.; Szabo, T.; Vekey, K., Direct tandem mass spectrometric analysis of amino acids in dried blood spots without chemical derivatization for neonatal screening. Rapid Communications in Mass Spectrometry 2003, 17, (9), 983-990.

34.      

Takats, Z.; Nanita, S. C.; Schlosser, G.; Vekey, K.; Cooks, R. G., Atmospheric pressure gas-phase H/D exchange of serine octamers. Analytical Chemistry 2003, 75, (22), 6147-6154.

35.      

Ouyang, Z.; Takats, Z.; Blake, T. A.; Gologan, B.; Guymon, A. J.; Wiseman, J. M.; Oliver, J. C.; Davisson, V. J.; Cooks, R. G., Preparing protein microarrays by soft-landing of mass-selected ions. Science 2003, 301, (5638), 1351-1354.

36.      

Takats, Z.; Schlosser, G.; Vekey, K., Hydrogen/deuterium exchange of electrosprayed ions in the atmospheric interface of a commercial triple-quadrupole mass spectrometer. International Journal of Mass Spectrometry 2003, 228, (2-3), 729-741.

37.      

Schlosser, G.; Takats, Z.; Vekey, K.; Pocsfalvi, G.; Malorni, A.; Windberg, E.; Kiss, A.; Hudecz, F., Mass spectrometric analysis of combinatorial peptide libraries derived from the tandem repeat unit of MUC2 mucin. Journal of Peptide Science 2003, 9, (6), 361-374.

38.      

Cooks, R. G.; Nanita, S. C.; Takats, Z.; Vekey, V.; Gozzo, F. C.; Eberlin, M. N., Homochiral clustering of serine: Implications for homochirogenesis. Abstracts of Papers of the American Chemical Society 2003, 225, 260-ANYL.

39.      

Takats, Z.; Nanita, S. C.; Cooks, R. G.; Schlosser, G.; Vekey, K., Amino acid clusters formed by sonic spray ionization. Analytical Chemistry 2003, 75, (6), 1514-1523.

40.      

Trezl, L.; Hullan, L.; Jaszay, Z. M.; Szarvas, T.; Petnehazy, I.; Szende, B.; Bocsi, J.; Takats, Z.; Vekey, K.; Toke, L., Antagonistic reactions of arginine and lysine against formaldehyde and their relation to cell proliferation, apoptosis, folate cycle and photosynthesis. Molecular and Cellular Biochemistry 2003, 244, (1), 167-176.

41.      

Koch, K. J.; Gozzo, F. C.; Nanita, S. C.; Takats, Z.; Eberlin, M. N.; Cooks, R. G., Chiral transmission between amino acids: Chirally selective amino acid substitution in the serine octamer as a possible step in homochirogenesis. Angewandte Chemie-International Edition 2002, 41, (10), 1721-+.

42.      

Takats, Z.; Drahos, L.; Schlosser, G.; Vekey, K., Feasibility of formation of hot ions in electrospray. Analytical Chemistry 2002, 74, (24), 6427-6429.

43.      

Riter, L. S.; Takats, Z.; Cooks, R. G., Single-sided membrane introduction mass spectrometry for on-line determination of semi-volatile organic compounds in air. Analyst 2001, 126, (11), 1980-1984.

44.      

Riter, L. S.; Takats, Z.; Charles, L.; Cooks, R. G., High surface area membrane introduction mass spectrometry for analysis of volatile and semi-volatile organic compounds in air. Rapid Communications in Mass Spectrometry 2001, 15, (17), 1520-1524.

45.      

Takats, Z.; Vekey, K.; Hegedus, L., Qualitative and quantitative determination of poloxamer surfactants by mass spectrometry. Rapid Communications in Mass Spectrometry 2001, 15, (10), 805-810.

46.      

Takats, Z.; Vargha, M.; Vekey, K., Investigation of atrazine metabolism in river sediment by high-performance liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry 2001, 15, (18), 1735-1742.

47.      

Takats, Z.; Koch, K. J.; Cooks, R. G., Organic chloramine analysis and free chlorine quantification by electrospray and atmospheric pressure chemical ionization tandem mass spectrometry. Analytical Chemistry 2001, 73, (18), 4522-4529.

48.      

Cooks, R. G.; Takats, Z.; Augusti, R.; Turowski, M.; Ritter, L. M., Process mass spectrometry using miniature traps and membrane introduction. Abstracts of Papers of the American Chemical Society 2001, 222, 193-ANYL.

49.      

Cooks, R. G.; Riter, L. S.; Koch, K. J.; Charles, L.; Badman, E.; Takats, Z., Miniature mass spectrometers with membrane interfaces for on-site. Abstracts of Papers of the American Chemical Society 2001, 221, 111-ENVR.

50.      

Kadar, M.; Takats, Z.; Karancsi, T.; Farsang, G., The role of halogen substituents in the electrooxidation of 4-halogenoanilines in neutral acetonitrile. Electroanalysis 1999, 11, (10-11), 809-813.

51.      

Takats, Z.; Vekey, K., Electrospray and atmospheric pressure chemical ionisation of aromatic compounds in dichloromethane solvent. European Mass Spectrometry 1998, 4, (5), 365-370.

52.      

Takats, Z.; Torkos, K., Determination of chlorobenzenes in environmental samples using solid phase microextraction, thermal desorption and analysis by gas chromatography coupled to FID, ECD, MSD IRD detectors. Chromatographia 1998, 48, (1-2), 74-8