Inhaltspezifische Aktionen

Biomedical Informatics and Systems Medicine


Next Generation Sequencing (NGS) based approaches represent a powerful tool to unravel different scientific questions aiming at studying the biology of our bodies’ cells. We use these methods to analyze genomes, transcriptomes, cistromes and even proteomes in unprecedented depth and in a systematic fashion. We use the information gathered by these approaches in order to study cellular processes in healthy and diseased cells, tissues and organisms. In order to interpret the vast amounts of experimental data acquisitioned by these techniques, we develop bioinformatics and systems biology approaches aiming at a more holistic understanding of the regulatory underpinnings of the processes governing cellular differentiation and the consequences of malfunctioning of these mechanisms in the context of disease. Next to our activities within basic scientific research, we support groups working at different levels of clinical sciences, involving large studies of cohorts in disease areas like infections of the lung, cancer or rare diseases

Latest publication

The H2A.Z and NuRD associated protein HMG20A controls early head and heart developmental transcription programs. Herchenröther A, Gossen S, Friedrich T, Reim A, Daus N, Diegmüller F, Leers J, Sani HM, Gerstner S, Schwarz L, Stellmacher I, Szymkowiak LV, Nist A, Stiewe T, Borggrefe T, Mann M, Mackay JP, Bartkuhn M, Borchers A, Lan J, Hake SB. Nat Commun. 2023 Jan 28;14(1):472. doi: 10.1038/s41467-023-36114-x. PMID: 36709316


Prof. Dr. Marek Bartkuhn

Biomedical Informatics and Systems Medicine
Science Unit for Basic and Clinical Medicine
Aulweg 128, Room 111
35392 Giessen

Phone: +49-641-99-30522 / +49-641-99-36470
Fax: +49-641-99-36479



Welcome Sophie!

We are excited to welcome Sophie-Marie Wind again. After joining our lab as an intern last year, she will now pursue her master‘s project on resistance mechanisms to inhibitors of oncogenic KRAS using bioinformatics and systems biology methods.