Inhaltspezifische Aktionen

Publikationen

Hier finden Sie die Publikationen der Sektion Experimentelle Chirurgie der letzten 6 Jahre.

  • Agné A, Richter K, Tumpara S, Sauer AL, Beckert F, Wrenger S, Zakrzewicz A, Hecker A, Markmann M, Koch C, Zajonz T, Sander M, Böning A, Padberg W, Janciauskiene S, Grau V.
    Does heart surgery change the capacity of α1-antitrypsin to inhibit the ATP-induced release of monocytic interleukin-1β? A preliminary study.
    Int Immunopharmacol. 2020 Feb 12;81:106297
    Abstract

  • Reichert M, Schistek M, Uhle F, Koch C, Bodner J, Hecker M, Hörbelt R, Grau V, Padberg W, Weigand MA, Hecker A.
    Ivor Lewis esophagectomy patients are particularly vulnerable to respiratory impairment - a comparison to major lung resection.
     Sci Rep. 2019 Aug 14;9(1):11856
    Abstract

  • Zakrzewicz A, Richter K, Zakrzewicz D, Siebers K, Damm J, Agné A, Hecker A, McIntosh JM, Chamulitrat W, Krasteva-Christ G, Manzini I, Tikkanen R, Padberg W, Janciauskiene S, Grau V.
    SLPI Inhibits ATP-Mediated Maturation of IL-1β in Human Monocytic Leukocytes: A Novel Function of an Old Player.
    Front Immunol. 2019 Apr 4;10:664. doi: 10.3389/fimmu.2019.00664. eCollection 2019.
    Abstract

  • Grau V, Richter K, Hone AJ, McIntosh JM.
    Conopeptides [V11L;V16D]ArIB and RgIA4: Powerful Tools for the Identification of Novel Nicotinic Acetylcholine Receptors in Monocytes.
    Front Pharmacol. 2019 Jan 7;9:1499.  eCollection 2018.
    Abstract

  • Richter K, Sagawe S, Hecker A, Küllmar M, Askevold I, Damm J, Heldmann S, Pöhlmann M, Ruhrmann S, Sander M, Schlüter KD, Wilker S, König IR, Kummer W, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz A, Koch C, Grau V.
    C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation.
    Front Immunol. 2018 Jul 30;9:1604.
    Abstract
  • Richter K, Koch C, Perniss A, Wolf PM, Schweda EKH, Wichmann S, Wilker S, Magel I, Sander M, McIntosh JM, Padberg W, Grau V.
    Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1β Release by Pulmonary Epithelial Cells.
    Molecules. 2018 Aug 8;23(8). pii: E1979.
    Abstract

  • Siebers K, Fink B, Zakrzewicz A, Agné A, Richter K, Konzok S, Hecker A, Zukunft S, Küllmar M, Klein J, McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau V.
    Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1β via CD36 and Nicotinic Acetylcholine Receptors.
    Front Immunol. 2018 Apr 25;9:877.
    Abstract

  • Hiller SD, Heldmann S, Richter K, Jurastow I, Küllmar M, Hecker A, Wilker S, Fuchs-Moll G, Manzini I, Schmalzing G, Kummer W, Padberg W, McIntosh JM, Damm J, Zakrzewicz A, Grau V.
    β-Nicotinamide Adenine Dinucleotide (β-NAD) Inhibits ATP-Dependent IL-1β Release from Human Monocytic Cells.
    Int J Mol Sci. 2018 Apr 10;19(4). pii: E1126.
    Abstract

  • Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA.
    OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
    Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539.
    Abstract

  • Amati AL, Zakrzewicz A, Siebers K, Wilker S, Heldmann S, Zakrzewicz D, Hecker A, McIntosh JM, Padberg W, Grau V.
    Chemokines (CCL3, CCL4, and CCL5) Inhibit ATP-Induced Release of IL-1β by Monocytic Cells.
    Mediators Inflamm. 2017;2017:1434872.
    Abstract

  • Schmitz J, Zakrzewicz A, Wilker S, Kuncová J, Hecker A, Grau V, Padberg W, Holler JPN.
    Non-neuronal neuropeptide Y and its receptors during acute rejection of rat pulmonary allografts.
    Transpl Immunol. 2017 Aug;43-44:49-53.
    Abstract

  • Backhaus S, Zakrzewicz A, Richter K, Damm J, Wilker S, Fuchs-Moll G, Küllmar M, Hecker A, Manzini I, Ruppert C, McIntosh JM, Padberg W, Grau V.
    Surfactant inhibits ATP-induced release of interleukin-1β via nicotinic acetylcholine receptors.
    J Lipid Res. 2017 Jun;58(6):1055-1066.
    Abstract
  • Soultanova A, Mikulski Z, Pfeil U, Grau V,, Kummer W.
    Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages.
    PLoS One. 2016 Oct 13;11(10):e0163483. 
    Abstract
  • Aggarwal N, Korenbaum E, Mahadeva R, Immenschuh S, Grau V, Dinarello CA, Welte T, Janciauskiene S. α-Linoleic acid enhances the capacity of α-1 antitrypsin to inhibit lipopolysaccharide-induced IL-1β in human blood neutrophils. Mol Med. 2016 Jul 13;22
    Abstract
  • Richter K, Mathes V, Fronius M, Althaus M, Hecker A, Krasteva-Christ G, Padberg W, Hone AJ, McIntosh JM, Zakrzewicz A, Grau V. Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors. Sci Rep. 2016 Jun 28;6:28660. 
    Abstract
  • Grau V, Zeuschner P, Immenschuh S, Bockmeyer CL, Zell S, Wittig J, Säuberlich K, Abbas M, Padberg W, Meyer-Schwesinger C, von Brandenstein M, Schlosser M, Dieplinger G, Galliford J, Clarke C, Roufosse C, Becker JU.
  • Immune Complex-Type Deposits in the Fischer-344 to Lewis Rat Model of Renal Transplantation and a Subset of Human Transplant Glomerulopathy. Transplantation. 2016 May;100(5):1004-14.
    Abstract
  • Koch C, Hecker A, Grau V, Padberg W, Wolff M, Henrich M.Intravenous immunoglobulin in necrotizing fasciitis - A case report and review of recent literature. Ann Med Surg (Lond). 2015 Aug 1;4(3):260-3
    Abstract
  • Hecker A, Küllmar M, Wilker S, Richter K, Zakrzewicz A, Atanasova S, Mathes V, Timm T, Lerner S, Klein J, Kaufmann A, Bauer S, Padberg W, Kummer W, Janciauskiene S, Fronius M, Schweda EK, Lochnit G, Grau V. Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1β Release. J Immunol. 2015 Sep 1;195(5):2325-34
    Abstract
  • Zakrzewicz A, Atanasova S, Padberg W, Grau V. Monocytic Tissue Transglutaminase in a Rat Model for Reversible Acute Rejection and Chronic Renal Allograft Injury. Mediators Inflamm. 2015;2015:429653. 
    Abstract
  • Zakrzewicz A, Kutlimuratov K, Atanasova S, Zakrzewicz D, Reichert M, Schmitz J, Wilhelm J, Lochnit G, Padberg W, Grau V. Attenuation of Acute Rat Renal Allograft Rejection by Apolipoprotein E-Mimetic Peptide. Transplantation. 2015 Feb 25.
    Abstract

  • Beckmann J1, Schubert J, Morhenn HG, Grau V, Schnettler R, Lips KS.
    Expression of choline and acetylcholine transporters in synovial tissue and cartilage of patients with rheumatoid arthritis and osteoarthritis.
    Cell Tissue Res. 2014 Nov 25. [Epub ahead of print]
    Abstract

  • Panneck AR1, Rafiq A, Schütz B, Soultanova A, Deckmann K, Chubanov V, Gudermann T, Weihe E, Krasteva-Christ G, Grau V, Del Rey A, Kummer W.

    Cholinergic epithelial cell with chemosensory traits in murine thymic medulla.
    Cell Tissue Res. 2014 Dec;358(3):737-48. Epub 2014 Oct 10.
    Abstract

  • Körner C, Kuchenbuch T, Pfeil U, Jung K, Padberg W, Kummer W, Mühlfeld C, Grau V.
    Low-dose adrenomedullin-2/intermedin(8-47) reduces pulmonary ischemia/reperfusion injury.Peptides. 2014 Oct 5. pii: S0196-9781(14)00291-5
    Abstract

  • Evers A, Atanasova S, Fuchs-Moll G, Petri K, Wilker S, Zakrzewicz A, Hirschburger M, Padberg W, Grau V.
    Adaptive and innate immune responses in a rat orthotopic lung transplant model of chronic lung allograft dysfunction.
    Transpl Int. 2014 Sep 1
    Abstract

  • Meixner M, Atanasova S, Padberg W, Grau V.
    Expression of acetylcholine receptors by experimental rat renal allografts.
    Biomed Res Int. 2014;2014:289656, Epub 2014 Jul 9.
    Abstract

  • Holler JP, Schmitz J, Roehrig R, Wilker S, Hecker A, Padberg W, Grau V.

    Expression of peptide YY by human blood leukocytes.
    Peptides. 2014 Jun 23. pii: S0196-9781(14)00155-7
    Abstract
  • Skwirba M, Zakrzewicz A, Atanasova S, Wilker S, Fuchs-Moll G, Müller D, Padberg W, Grau V.
    Expression of nestin after renal transplantation in the rat.
    APMIS. 2014 Apr 4
    Abstract
  • Atanasova S, Hirschburger M, Jonigk D, Obert M, Petri K, Evers A, Hecker A, Schmitz J, Kaufmann A, Wilhelm J, Chakraborty T, Warnecke G, Gottlieb J, Padberg W, Grau V. A relevant experimental model for human bronchiolitis obliterans syndrome. J Heart Lung Transplant. 2013 Nov;32(11):1131-9. doi: 10.1016/j.healun.2013.07.016. Epub 2013 Sep 16.
    Abstract
  • Zakrzewicz D, Zakrzewicz A, Preissner KT, Markart P, Wygrecka M.
    Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders. Int J Mol Sci. 2012 Sep 27;13(10):12383-400. doi: 10.3390/ijms131012383-
    Abstract
  • Grau V, Fuchs-Moll G, Wilker S, Weimer R, Padberg W.
    Proliferation of CD8-positive T cells in blood vessels of rat renal allografts.
    Am J Transplant. 2011 Sep;11(9):1979-85. doi: 10.1111/j.1600-6143.2011.03642.x. Epub 2011 Aug 9.
    Abstract
  • Seifart C, Muyal JP, Plagens A, Yildirim AÖ, Kohse K, Grau V, Sandu S, Reinke C, Tschernig T, Vogelmeier C, Fehrenbach H.
    All-trans retinoic acid results in irregular repair of septa and fails to inhibit proinflammatory macrophages.
    Eur Respir J. 2011 Aug;38(2):425-39. Epub 2011 Jan 27.
    Abstract
  • Wilczynska J, Pfeil U, Zakrzewicz A, Dietrich H, Körner C, Hecker A, Wessler I, Padberg W, Kummer W, Grau V. Acetylcholine and chronic vasculopathy in rat renal allografts. Transplantation. 2011 Feb 15;91(3):263-70.
    Abstract
  • Zakrzewicz A, Krasteva G, Wilhelm J, Dietrich H, Wilker S, Padberg W, Wygrecka M, Grau V. Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. Immunobiology. 2011 Jul;216(7):854-61. Epub 2010 Dec 3.
    Abstract
  • Zakrzewicz A, Wilhelm J, Blöcher S, Wilczynska J, Wilker S, Dietrich H, Weimer R, Padberg W, Grau V. Leukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys. Immunobiology. 2011 May;216(5):613-24. Epub 2010 Sep 24.
    Abstract
  • Mikulski Z, Hartmann P, Jositsch G, Zaslona Z, Lips KS, Pfeil U, Kurzen H, Lohmeyer J, Clauss WG, Grau V, Fronius M, Kummer W.
    Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration.
    Respir Res. 2010 Sep 29;11:133.
    Abstract
  • Hecker M, Zaslona Z, Kwapiszewska G, Niess G, Zakrzewicz A, Hergenreider E, Wilhelm J, Marsh LM, Sedding D, Klepetko W, Lohmeyer J, Dimmeler S, Seeger W, Weissmann N, Schermuly RT, Kneidinger N, Eickelberg O, Morty RE.
    Dysregulation of the IL-13 receptor system: a novel pathomechanism in pulmonary arterial hypertension.
    Am J Respir Crit Care Med. 2010 Sep 15;182(6):805-18. Epub 2010 Jun
    Abstract
  • Holler J, Zakrzewicz A, Garn H, Hirschburger M, Kummer W, Padberg W, Grau V. Increased expression of epidermal fatty acid-binding protein by alveolar macrophages during acute rejection of rat lungs. APMIS. 2010 Oct;118(10):791-800. doi: 10.1111/j.1600-0463.2010.02662.x. Epub 2010 Aug 17. Abstract
  • Zakrzewicz D, Zakrzewicz A, Wilker S, Boedeker RH, Padberg W, Eickelberg O, Grau V. Dimethylarginine metabolism during acute and chronic rejection of rat renal allografts. Nephrol Dial Transplant. 2011 Jan;26(1):124-35. Epub 2010 Jul 19.
    Abstract
  • Paddenberg R, Howold N, Hoger C, Janssen H, Grau V, Kummer W. Organ preservation solutions attenuate accumulation and nuclear translocation of hypoxia-inducible factor-1alpha in the hepatoma cell line HepG2 Cell Biochem Funct. 2009 Dec;27(8):516-25.
    Abstract
  • Ploetz C, Janssen H, Zakrzewicz A, Paddenberg R, Padberg W, Kummer W, Grau V. Fumarate in the preservation solution aggravates chronic allograft nephropathy. J Surg Res. 2011 Apr;166(2):306-13. Epub 2009 Jun 27.
    Abstract
  • Hirschburger M, Zakrzewicz A, Kummer W, Padberg W, Grau V. Nicotine attenuates macrophage infiltration in rat lung allografts. J Heart Lung Transplant. 2009 May;28(5):493-500.
    Abstract
  • Hecker A, Mikulski Z, Lips KS, Pfeil U, Zakrzewicz A, Wilker S, Hartmann P, Padberg W, Wessler I, Kummer W, Grau V. Pivotal Advance: Up-regulation of acetylcholine synthesis and paracrine cholinergic signaling in intravascular transplant leukocytes during rejection of rat renal allografts. J Leukoc Biol. 2009 Jul;86(1):13-22. Epub 2009 Apr 30.
    Abstract
  • Greschus S, Kuchenbuch T, Plötz C, Obert M, Traupe H, Padberg W, Grau V, Hirschburger M. Monitoring of experimental rat lung transplants by high-resolution flat-panel volumetric computer tomography (fpVCT). J Invest Surg. 2009 Jan-Feb;22(1):69-75.
    Abstract
  • Hecker A, Kaufmann A, Hecker M, Padberg W, Grau V. Expression of interleukin-21, interleukin-21 receptor alpha and related type I cytokines by intravascular graft leukocytes during acute renal allograft rejection. Immunobiology. 2009;214(1):41-9. Epub 2008 Jun 17.
    Abstract
  • Holler J, Zakrzewicz A, Kaufmann A, Wilhelm J, Fuchs-Moll G, Dietrich H, Padberg W, Kuncová J, Kummer W, Grau V. Neuropeptide Y is expressed by rat mononuclear blood leukocytes and strongly down-regulated during inflammation. J Immunol. 2008 Nov 15;181(10):6906-12.
    Abstract
  • Hirschburger M, Obert M, Traupe H, Kuchenbuch T, Padberg W, Fehrenbach H, Grau V. Treatment with keratinocyte growth factor does not improve lung allograft survival in the rat. Langenbecks Arch Surg. 2009 Jan;394(1):133-41. Epub 2008 Feb 19.
    Abstract
  • Hoerbelt R, Benjamin CL, Shoji T, Houser SL, Muniappan A, Hasse RS, Ledgerwood LG, Allan JS, Sachs DH, Madsen JC. The effects of tolerance on allograft damage caused by the innate immune system. Transplantation 85:314-322 (2008)
    Abstract
  • Kwapiszewska G, Wygrecka M, Marsh LM, Schmitt S, Trösser R, Wilhelm J, Helmus K, Eul B, Zakrzewicz A, Ghofrani HA, Schermuly RT, Bohle RM, Grimminger F, Seeger W, Eickelberg O, Fink L, Weissmann N. Fhl-1, a new key protein in pulmonary hypertension. Circulation. 2008 Sep 9;118(11):1183-94. Epub 2008 Aug 25.
    Abstract
  • Hirschburger M, Sauer S, Schwandner T, Schief W, Kuchenbuch T, Zoerb C, Janssen H, Grau V, Stertmann W, Rau WS, Padberg W. Extratumoral spiral fixed wire marking of small pulmonary nodules for thoracoscopic resection. Thorac Cardiovasc Surg. 2008 Mar;56(2):106-9.
    Abstract
  • Sadovski J, Kuchenbuch T, Ruppert C, Fehrenbach A, Hirschburger M, Padberg W, Günther A, Hohlfeld JM, Fehrenbach H, Grau V. Keratinocyte growth factor prevents intra-alveolar oedema in experimental lung isografts. Eur Respir J. 2008 Jan;31(1):21-8. Epub 2007 Oct 10.
    Abstract
  • Grau V, Wilker S, Lips KS, Hartmann P, Rose F, Padberg W, Fehrenbach H, Wessler I, Kummer W. Administration of keratinocyte growth factor down-regulates the pulmonary capacity of acetylcholine production. Int J Biochem Cell Biol. 2007;39(10):1955-63. Epub 2007 May 31.
    Abstract
  • Blöcher S, Wilker S, Sucke J, Pfeil U, Dietrich H, Weimer R, Steger K, Kaufmann A, Hirschburger M, Plötz C, Padberg W, Grau V. Acute rejection of experimental lung allografts: characterization of intravascular mononuclear leukocytes. Clin Immunol. 2007 Jul;124(1):98
    Abstract
  • Grau V, Fuchs-Moll G, Krasteva G, Hirschburger M, Steiniger B, Padberg W. Donor B cells in splenic follicles of experimental pulmonary allograft recipients. Langenbecks Arch Surg. 2008 Mar;393(2):219-26. Epub 2007 Apr 14.
    Abstract
  • Zakrzewicz A, Hecker M, Marsh LM, Kwapiszewska G, Nejman B, Long L, Seeger W, Schermuly RT, Morrell NW, Morty RE, Eickelberg O. Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension. Circulation. 2007 Jun 12;115(23):2957-68. Epub 2007 May
    Abstract
  • Morty RE, Nejman B, Kwapiszewska G, Hecker M, Zakrzewicz A, Kouri FM, Peters DM, Dumitrascu R, Seeger W, Knaus P, Schermuly RT, Eickelberg O. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1072-8. Epub 2007 Mar
    Abstract
  • Hirschburger M, Greschus S, Kuchenbuch T, Plötz C, Obert M, Traupe H, Padberg W, Grau V. Lung transplantation in the Fischer 344-->Wistar Kyoto rat strain combination is not suitable to study bronchiolitis obliterans. J Heart Lung Transplant. 2007 Apr;26(4):390-8.
    Abstract
  • Biallas S, Wilker S, Lips KS, Kummer W, Grando SA, Padberg W, Grau V. Immunohistochemical detection of nicotinic acetylcholine receptor subunits alpha9 and alpha10 in rat lung isografts and allografts. Life Sci. 2007 May 30;80(24-25):2286-9. Epub 2007 Feb 1.
    Abstract
  • Lips KS, Lührmann A, Tschernig T, Stoeger T, Alessandrini F, Grau V, Haberberger RV, Koepsell H, Pabst R, Kummer W. Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse. Life Sci. 2007 May 30;80(24-25):2263-9. Epub 2007 Jan 23.
    Abstract
  • Grau V, Wilker S, Hartmann P, Lips KS, Grando SA, Padberg W, Fehrenbach H, Kummer W. Administration of keratinocyte growth factor (KGF) modulates the pulmonary expression of nicotinic acetylcholine receptor subunits alpha7, alpha9 and alpha10. Life Sci. 2007 May 30;80(24-25):2290-3. Epub 2007 Jan 23.
    Abstract
  • Hecker A, Lips KS, Pfeil U, Kummer W, Padberg W, Grau V. Peripheral choline acetyltransferase is expressed by monocytes and upregulated during renal allograft rejection in rats. J Mol Neurosci. 2006;30(1-2):23-4.
    Abstract
  • Schmidt A, Sucke J, Fuchs-Moll G, Freitag P, Hirschburger M, Kaufmann A, Garn H, Padberg W, Grau V. Macrophages in experimental rat lung isografts and allografts: infiltration and proliferation in situ. J Leukoc Biol. 2007 Jan;81(1):186-94. Epub 2006 Oct 19.
    Abstract
  • Groth M, Helbig T, Grau V, Kummer W, Haberberger RV. Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels. Respir Res. 2006 Jul 1;7:96.
    Abstract
  • Grau V, Garn H, Holler J, Rose F, Blöcher S, Hirschburger M, Fehrenbach H, Padberg W. Epidermal fatty acid-binding protein is increased in rat lungs following in vivo treatment with keratinocyte growth factor. Int J Biochem Cell Biol. 2006
    Feb;38(2):279-87. Epub 2005 Oct 3.
    Abstract