SFB 1021,"RNA Viruses: RNA Metabolism, Host Response and Pathogenesis", project Z03

Short summary:

Infection of target cells by RNA viruses result in the rapid reprogramming of cellular signalling, post-translational modifications (PTMs), protein interaction networks and translation rates. Z03 will provide a versatile and state of the art proteomics and bioinformatics platform to enable the proteome-wide investigation and quantification of (i) protein interactions / interactomes, (ii) protein expression levels, (iii) proteins undergoing de novo synthesis (translatomes), (iv) (regulated) PTMs and (iv) individual (purified) proteins. A broad spectrum of follow-up bioinformatics (meta-)analyses will be utilized to achieve a more holistic view on the molecular interactions during RNA virus infections.

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