AG Kilchert
Pre-prints under Review
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Wäber, N.B.*, Seidler, J.*, Thelen, F.*, Kot, P., Schreiner, S., Timm, T., Bettenworth, V., Lochnit, G., Sträßer, K.,
Kilchert, C
. (2026) "Cross-species profiling reveals a conserved core of RNA-dependent proteins in yeast."
bioRxiv
, 10.1101/2024.12.06.627129 - * shared authorship
DOI: 10.1101/2024.12.06.627129 -
Au, A.; Southers., A; Kus, K.; Schoemaker, N.; Balikci-Akil, E.; Aydin, A.; Hewes, C.; Fournier, M.; Hassanein, S.;
Kilchert, C.
; Grimes, J.M.; Vasiljeva, L. (2025) "The PP1 phosphatase complex coordinates pre-mRNA 3’end processing and termination of RNA polymerase II transcription"
bioRxiv
, 10.1101/2025.12.17.694969
DOI: 10.1101/2025.12.17.694969
Published works
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Kilchert, C.
, Sträßer, K. (2026) “LENG8: The nuclear sentry guarding against aberrant RNA leakage.”
Mol. Cell
, 86, 1417-1418.
DOI: 10.1016/j.molcel.2026.03.026 -
Braun, S.*,
Kilchert, C.
*, Bulut-Karslioglu, A., Ruault, M., Taddei, A., Rabbani, F., & Włoch-Salamon, D. (2026) “Nuclear Dynamics in Quiescent Cells: Conserved Mechanisms from Yeasts to Mammals.”
Biomolecules
, 16(2), 203.
DOI: 10.3390/biom16020203 -
Kuś, K., Carrique, L., Kecman, T., Fournier, M., Hassanein, S.S., Aydin, E.,
Kilchert, C.
, Grimes, J.M., Vasiljeva, L. (2025) “DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts.”
Nat. Commun.
16(1), 1–19
.
DOI: 10.1038/s41467-024-55063-7 -
Aydin, E., Böhme, J., Keil, B., Schreiner, S., Žunar, B., Glatter, T.,
Kilchert, C.
(2024) “DEAD-box ATPase Dbp2 is the key enzyme in an mRNP assembly checkpoint at the 3’-end of genes and involved in the recycling of cleavage factors.”
Nat. Commun.
15(1):1–20
.
DOI: 10.1038/s41467-024-51035-z -
Kilchert, C
. (2022) “RNA-protein interactomics” in “Protein Interactions: The Molecular Basis of Interactomics”, Eds. Volkhard Helms & Olga Kalinina, Wiley-VCH, ISBN: 978-3-527-34864-0
DOI: 10.1002/9783527830503.ch12 -
Birot, A., Kus, K., Priest, E., Alwash, A. Al, Castello, A., Mohammed, S., Vasiljeva, L. and
Kilchert, C
. (2021) RNA-binding protein Mub1 and the nuclear RNA exosome act to fine-tune environmental stress response.
Life Sci. Alliance
, 5, e202101111.
DOI: 10.26508/lsa.202101111 -
Kilchert, C
., Kecman, T., Priest, E., Hester, S., Aydin, E., Kus, K., Rossbach, O., Castello, A., Mohammed, S., Vasiljeva, L. (2020) “System-wide analyses of the fission yeast poly(A)+RNA interactome reveal insights into organization and function of RNA-protein complexes.”
Genome Res.
30(7):1012–1026.
DOI: 10.1101/gr.257006.119 -
Kilchert, C
. (2020) “RNA exosomes and their co-factors.”
Methods Mol Biol.
2062:215-235.
DOI 10.1007/978-1-4939-9822-7_11 -
Kilchert, C
. Hester, S., Castello, A., Mohammed, S., Vasiljeva, L. (2020) “Comparative poly(A)+ RNA interactome capture of RNA surveillance mutants.”
Methods Mol Biol.
2062:255-276.
DOI: 10.1007/978-1-4939-9822-7_13 -
Kilchert, C
., Sträßer, K., Kunetsky, V., Änkö, M.L. (2019) “From parts lists to functional significance—RNA–protein interactions in gene regulation.”
Wiley Interdiscip Rev RNA
:e1582. - Review
DOI: 10.1002/wrna.1582 -
Watts, B.R., Wittmann, S., Wery, M., Gautier, C., Kus, K., Birot, A., Heo, D.H.,
Kilchert, C
., Morillon, A., Vasiljeva, L. (2018) “Histone deacetylation promotes transcriptional silencing at facultative heterochromatin.”
Nucleic Acids Res.
46(11):5426-5440.
DOI: 10.1093/nar/gky232 -
Wittmann, S., Renner, M., Watts, B., Adams, O., Huseyin, M., Baejen, C., El Omari,
Kilchert, C
., Heo, D.H., Kecman, T., Cramer, P., Grimes, J., Vasiljeva, L. (2017) “The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA”
Nat Commun.
8:14861.
DOI: 10.1038/ncomms14861 -
Kilchert, C
., Wittmann, S., Vasiljeva, L. (2016) “The regulation and functions of the nuclear RNA exosome complex”
Nat Rev Mol Cell Biol.
17(4):227-39. - Review
DOI: 10.1038/nrm.2015.15 -
Kilchert, C
., Wittmann, S., Passoni, M., Shah, S., Granneman, S., Vasiljeva, L. (2015) “Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1”
Cell Rep.
13(11):2504-15.
DOI: 10.1016/j.celrep.2015.11.026 -
Shah, S., Wittmann, S.*,
Kilchert, C
.*, Vasiljeva, L. (2014) “lncRNA recruits RNAi and the exosome to dynamically regulate
pho1
expression in response to phosphate levels in fission yeast”
Genes Dev.
28(3):231-44. *These authors contributed equally
DOI: 10.1101/gad.230177.113 -
Kilchert, C
., Vasiljeva, L. (2013) “mRNA quality control goes transcriptional”
Biochem Soc Trans.
41(6):1666-72. - Review
DOI: 10.1042/BST20130202 -
Volanakis, A., Passoni, M., Hector R.D., Shah, S.,
Kilchert, C
., Granneman, S., Vasiljeva, L. (2013) “Spliceosome-mediated decay (SMD) regulates expression of nonintronic genes in budding yeast”
Genes Dev.
27(18):2025-38.
DOI: 10.1101/gad.221960.113 -
Kilchert, C
., Spang, A. (2011) „ Cotranslational transport of ABP140 mRNA to the distal pole of S. cerevisiae
.
”
EMBO J.
30(17):3567-80.
DOI: 10.1038/emboj.2011.247
Commented on in: Yoo, S., Twiss, J.L. (2011) “The road not taken: New destinations for yeast mRNAs on the move.” EMBO J. 30(17):3564–3566. -
Kilchert, C.
, Weidner, J., Prescianotto-Baschong, C., Spang, A. (2010) „Defects in the secretory pathway and high Ca
2+
induce multiple P-bodies.”
Mol Biol Cell.
21(15):2624-38.
DOI: 10.1091/mbc.e10-02-0099 -
Kamena, F., Diefenbacher, M., Kilchert, C ., Schwarz, H., Spang, A. (2008) „Ypt1p is essential for retrograde Golgi-ER transport and for Golgi maintenance in S. cerevisiae.” J. Cell Sci . 121(8):1293-302.
DOI: 10.1242/jcs.016998