Inhaltspezifische Aktionen

Publikationen Prof. Dr. El Khassawna

2023                                               - under construction -

 

  • Malhan D, Schmidt-Bleek K, Duda GN, El Khassawna T. Landscape of Well-Coordinated Fracture Healing in a Mouse Model Using Molecular and Cellular Analysis. Int J Mol Sci. 2023 Feb 10;24(4):3569. doi: 10.3390/ijms24043569. PMID: 36834981; PMCID: PMC9964763.
  • Pawelke J, Vinayahalingam V, El Khassawna T, Heiss C, Eckl L, Knapp G. Complication and Infection Risk Using Bone Substitute Materials to Treat Long Bone Defects in Geriatric Patients: An Observational Study. Medicina (Kaunas). 2023 Feb 14;59(2):365. doi: 10.3390/medicina59020365. PMID: 36837565; PMCID: PMC9962159.
  • Thieu MKL, Stoetzel S, Rahmati M, El Khassawna T, Verket A, Sanz-Esporrin J, Sanz M, Ellingsen JE, Haugen HJ. Immunohistochemical comparison of lateral bone augmentation using a synthetic TiO2 block or a xenogeneic graft in chronic alveolar defects. Clin Implant Dent Relat Res. 2023 Feb;25(1):57-67. doi: 10.1111/cid.13143. Epub 2022 Oct 12. PMID: 36222116; PMCID: PMC10092822.
  • Pawelke J, Vinayahalingam V, Heiss C, Khassawna TE, Knapp G. Retrospective Analysis of Bone Substitute Material for Traumatic Long Bone Fractures: Sex-Specific Outcomes. Int J Mol Sci. 2023 Sep 18;24(18):14232. doi: 10.3390/ijms241814232. PMID: 37762534; PMCID: PMC10532127.
  • Knapp G, Pawelke J, Heiss C, Elmas S, Vinayahalingam V, ElKhassawna T. Traumatic Fracture Treatment: Calcium Phosphate Bone Substitute Case-Control Study in Humerus, Radius, Tibia Fractures-Assessing Efficacy and Recovery Outcomes. Biomedicines. 2023 Oct 22;11(10):2862. doi: 10.3390/biomedicines11102862. PMID: 37893234; PMCID: PMC10604612.
  • Pawelke J, Vinayahalingam V, Heiss C, Budak M, El Khassawna T, Knapp G. Comparison of Nanocrystalline Hydroxyapatite Bone Graft with Empty Defects in Long Bone Fractures: A Retrospective Case-Control Study. Med Sci Monit. 2023 Oct 24;29:e941112. doi: 10.12659/MSM.941112. PMID: 37872747; PMCID: PMC10612429.

 

2022

  • Thieu MKL, Stoetzel S, Rahmati M, El Khassawna T, Verket A, Sanz-Esporrin J, Sanz M, Ellingsen JE, Haugen HJ. Immunohistochemical comparison of lateral bone augmentation using a synthetic TiO2 block or a xenogeneic graft in chronic alveolar defects. Clin Implant Dent Relat Res. 2023 Feb;25(1):57-67.
  • Kern C, Jamous R, El Khassawna T, Rohnke M. Characterisation of Sr2+ mobility in osteoporotic rat bone marrow by cryo-ToF-SIMS and cryo-OrbiSIMS. Analyst. 2022 Sep 12;147(18):4141-4157.
  • Mendelsohn DH, Schnabel K, Mamilos A, Sossalla S, Pabel S, Duerr GD, Keller K, Schmitt VH, Barsch F, Walter N, Wong RMY, El Khassawna T, Niedermair T, Alt V, Rupp M, Brochhausen C. Structural Analysis of Mitochondrial Dynamics-From Cardiomyocytes to Osteoblasts: A Critical Review. Int J Mol Sci. 2022 Apr 20;23(9):4571.
  • Timm K, Walter N, Heinrich M, Knapp G, Thormann U, El Khassawna T, Alt V, Heiss C, Rupp M. Influence of Thoracic Trauma on Fracture Healing in Long Bones-A Retrospective Analysis. J Clin Med. 2022 Jan 28;11(3):717.

2021

  • Stoetzel S, Malhan D, Wild U, Helbing C, Hassan F, Attia S, Jandt KD, Heiss C, El Khassawna T. Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae. Int J Mol Sci. 2021 Dec 29;23(1):374.
  • Alkhasawnah Q, Elmas S, Sohrabi K, Attia S, Heinemann S, El Khassawna T, Heiss C. Confirmation of Calcium Phosphate Cement Biodegradation after Jawbone Augmentation around Dental Implants Using Three-Dimensional Visualization and Segmentation Software. Materials (Basel). 2021 Nov 22;14(22):7084.
  • El Khassawna T, Knapp G, Scheibler N, Malhan D, Walter N, Biehl C, Alt V, Heiss C, Rupp M. Mortality, Risk Factors and Risk Assessment after Periprosthetic Femoral Fractures-A Retrospective Cohort Study. J Clin Med. 2021 Sep 23;10(19):4324.
  • Hemm F, Fijak M, Belikan J, Kampschulte M, El Khassawna T, Pilatz A, Heiss C, Lips KS. Bone Status in a Mouse Model of Experimental Autoimmune-Orchitis. Int J Mol Sci. 2021 Jul 23;22(15):7858.
  • Biehl C, Schmitt J, Stoetzel S, Malhan D, Hassan F, Knapp G, Heiss C, El Khassawna T. DXA reference values of the humanoid sheep model in preclinical studies. PeerJ. 2021 Apr 30;9:e11183.
  • Maurer E, Walter N, Histing T, Anastasopoulou L, El Khassawna T, Wenzel L, Alt V, Rupp M. Awareness of predatory journals and open access publishing among orthopaedic and trauma surgeons - results from an online survey in Germany. BMC Musculoskelet Disord. 2021 Apr 17;22(1):365.
  • Rupp M, Biehl C, Malhan D, Hassan F, Attia S, Rosch S, Schäfer AB, McMahon E, Kampschulte M, Heiss C, El Khassawna T. Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model. Life (Basel). 2021 Mar 19;11(3):254.

2020

  • Pfeiffer K, El Khassawna T, Malhan D, Langer C, Sommer B, Mekhemar M, Howaldt HP, Attia S. Is Biofeedback through an Intra-Aural Device an Effective Method to Treat Bruxism? Case Series and Initial Experience. Int J Environ Res Public Health. 2020 Dec 23;18(1):51.
  • Kruppke B, Ray S, Alt V, Rohnke M, Kern C, Kampschulte M, Heinemann C, Budak M, Adam J, Döhner N, Franz-Forsthoffer L, El Khassawna T, Heiss C, Hanke T, Thormann U. Gelatin-Modified Calcium/Strontium Hydrogen Phosphates Stimulate Bone Regeneration in Osteoblast/Osteoclast Co-Culture and in Osteoporotic Rat Femur Defects-In Vitro to In Vivo Translation. Molecules. 2020 Nov 3;25(21):5103.
  • Biehl C, Rupp M, Kern S, Heiss C, ElKhassawna T, Szalay G. Extensor tendon ruptures in rheumatoid wrists. Eur J Orthop Surg Traumatol. 2020 Dec;30(8):1499-1504.
  • Mutsenko V, Knaack S, Lauterboeck L, Tarusin D, Sydykov B, Cabiscol R, Ivnev D, Belikan J, Beck A, Dipresa D, Lode A, El Khassawna T, Kampschulte M, Scharf R, Petrenko AY, Korossis S, Wolkers WF, Gelinsky M, Glasmacher B, Gryshkov O. Effect of 'in air' freezing on post-thaw recovery of Callithrix jacchus mesenchymal stromal cells and properties of 3D collagen-hydroxyapatite scaffolds. Cryobiology. 2020 Feb 1;92:215-230.

2019

  • Maurer E, Walter N, Histing T, Anastasopoulou L, El Khassawna T, Wenzel L, Alt V, Rupp M. Awareness of predatory journals and open access publishing among orthopaedic and trauma surgeons - results from an online survey in Germany. BMC Musculoskelet Disord. 2021 Apr 17;22(1):365.
  •  Attia S, Schaaf H, El Khassawna T, Malhan D, Mausbach K, Howaldt HP, Streckbein P. Oral Rehabilitation of Hypodontia Patients Using an Endosseous Dental Implant: Functional and Aesthetic Results. J Clin Med. 2019 Oct 15;8(10):1687.
  •  Rupp M, Kern S, Ismat A, El Khassawna T, Knapp G, Szalay G, Heiss C, Biehl C. Computed tomography for managing periprosthetic femoral fractures. A retrospective analysis. BMC Musculoskelet Disord. 2019 May 29;20(1):258.
  •  Müller R, Henss A, Kampschulte M, Rohnke M, Langheinrich AC, Heiss C, Janek J, Voigt A, Wilke HJ, Ignatius A, Herfurth J, El Khassawna T, Deutsch A. Analysis of microscopic bone properties in an osteoporotic sheep model: a combined biomechanics, FE and ToF-SIMS study. J R Soc Interface. 2019 Feb 28;16(151):20180793.
  •  Rupp M, Kern S, El Khassawna T, Ismat A, Malhan D, Alt V, Heiss C, Raschke MJ. Do Systemic Factors Influence the Fate of Nonunions to Become Atrophic? A Retrospective Analysis of 162 Cases. Biomed Res Int. 2019 Feb 19;2019:6407098.
  •  Attia S, Wiltfang J, Streckbein P, Wilbrand JF, El Khassawna T, Mausbach K, Howaldt HP, Schaaf H. Functional and aesthetic treatment outcomes after immediate jaw reconstruction using a fibula flap and dental implants. J Craniomaxillofac Surg. 2019 May;47(5):786-791.
  •  Rupp M, Merboth F, Daghma DE, Biehl C, El Khassawna T, Heiß C. Osteocytes. Z Orthop Unfall. 2019 Apr;157(2):154-163. English, German.
  •  Rupp M, Anastasopoulou L, Wintermeyer E, Malhaan D, El Khassawna T, Heiss C. Predatory journals: a major threat in orthopaedic research. Int Orthop. 2019 Mar;43(3):509-517.

2018

  • Ray S, Thormann U, Eichelroth M, Budak M, Biehl C, Rupp M, Sommer U, El Khassawna T, Alagboso F.I, Kampschulte M, Rohnke M, Henß A, Peppler K, Linke V, Quadbeck P, Voigt A, Stenger F, Karl D, Schnettler R, Heiss C, Lips K.S, Alt V. Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing, Biomaterials 2018.

Ältere Publikationen

2017

  • Al Khasawnah Q, Hassan F, Malhan M, Engelhardt M, Daghma D.S, Obidat D, Lips KS, El Khassawna T, Heiss C. Non-Surgical Clinical Management of Periapical Lesions Using Calcium Hydroxide-Iodoform-Silicon-oil Paste. BioMed Res Int. 2017.
  • Schulze F, Malhan D, El Khassawna T, Heiss C, Seckinger A, Hose D, Rösen-Wolff A. A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model. BMC Genomics. 2017.
  • Heiss C, Kern S, Malhan D, Böcker W, Engelhardt M, Daghma DES, Stoetzel S, Schmitt J, Ivo M, Kauschke V, Lips KS, Tushtev K, Rezwan K, El Khassawna T. A New Clinically Relevant T-Score Standard to Interpret Bone Status in a Sheep Model. Med Sci Monit Basic Res 2017. [OA]
  • Schumacher TC, Tushtev K, Wagner U, Becker C, Große Holthaus M, Hein SB, Haack J, Heiss C, Engelhardt M, El Khassawna T, Rezwan K. A novel, hydroxyapatite-based screw-like device for anterior cruciate ligament (ACL) reconstructions. The Knee 2017. [OA]
  • El Khassawna T, Merboth F, Bocker W, Malhan D, Daghma DS, Stözel S, Kern S, Hassan F, Rosenbaum D, Langenstein J, Bauer N, Schlagenhauf A, Rösen-wolff A, Schulze F, Rupp M, Hose D, Secklinger A, Ignatius A, Wilke HJ, S. LK, Heiss C. Osteocytes regulation of Receptor Activator of NF- κB Ligang/Osteoprotegerin in a Sheep Model of Osteoporosis. Am J Pathol. 2017.
  • Daghma DES, Malhan D, Simon P, Stötzel S, Kern S, Hassan F, Lips KS, Heiss C, El Khassawna T. Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine. J Bone Miner Metab. 2017.
  • El Khassawna T, Serra A, Bucher CH, Petersen A, Schlundt C, Könnecke I, Malhan D, Wendler S, Schell H, Volk H-D, Schmidt-Bleek K, Duda GN: T Lymphocytes Influence the Mineralization Process of Bone. Front Immunol 2017, 8. [OA]
  • El Khassawna T, Daghma DES, Stoetzel S, Ray S, Kern S, Malhan D, Alt V, Thromann U, Henß A, Rohnke M, Stengel A, Hassan F, Maenz S, Jandt KD, Diefenbeck M, Schumacher M, Gelinsky M, Lips KS, Heiss C. Postembedding Decalcification of Mineralized Tissue Sections Preserves the Integrity of Implanted Biomaterials and Minimizes Number of Experimental Animals. BioMed Res Int. 2017. [OA]

 

2016

  • Kampschulte M, Krombach GA, Richards DC, Sender J, Lips KS, Thormann U, El Khassawna T, Ray S, Alt V, Langheinrich AC. Neovascularization of osteoporotic metaphyseal bone defects: A morphometric micro-CT study. Microvasc Res. 2016. [OA]
  • Ray S, Thormann U, Sommer U, El Khassawna T, Hundgeburth M, Henß A, Rohnke M, Lips KS, Heiss C, Heinemann S, Hanke T, Dürselen L, Schnettler R, Alt V. Effects of macroporous, strontium loaded xerogel-scaffolds on new bone formation in critical-size metaphyseal fracture defects in ovariectomized rats. Injury. 2016. [OA]
  • Ray S, Khassawna TE, Sommer U, Thormann U, Wijekoon ND, Lips K, Heiss C,Alt V. Differences in expression of Wnt antagonist Dkk1 in healthy versus pathological bone samples. J Microsc. 2016

 

2015

  • El Khassawna T, Bocker W, Brodsky K, Weisweiler D, Govindarajan P, Kampschulte M, Thormann U, Henss A, Rohnke M, Bauer N, Muller R, Deutsch A, Ignatius A, Durselen L, Langheinrich A, Lips KS, Schnettler R, Heiss C. Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats. Histochem Cell Biol. 2015
  • Schlundt C*, El Khassawna T*, Serra A, Dienelt A, Wendler S, Schell H, van Rooijen N, Radbruch A, Lucius R, Hartmann S, Duda GN, Schmidt-Bleek K. Macrophages in bone fracture healing: Their essential role in endochondral ossification. Bone. 2015. (Equal contribution) [OA]
  • Bauer NB, El Khassawna T, Goldmann F, Stirn M, Ledieu D, Schlewitz G, Govindarajan P, Zahner D, Weisweiler D, Schliefke N, Böcker W, Schnettler R, Heiss C, Moritz A. Characterization of bone turnover and energy metabolism in a rat model of primary and secondary osteoporosis. Exp Toxicol Pathol. 2015. [OA]
  • Kampschulte M, Erdmann G, Sender J, Martels G, Böcker W, El Khassawna T, Heiss C, Langheinrich AC, Roeb E, Roderfeld M. The development and validation of micro‐CT of large deep frozen specimens. Scanning. 2015. [OA]

 

2014

  • Bocker W, El Khassawna T, Bauer N, Brodsky K, Weisweiler D, Govindarajan P, Schlewitz G, Kampschulte M, Durselen L, Thormann U, Szalay G, Schnettler R, Langheinrich AC, Heiss C. Short-term glucocorticoid treatment causes spinal osteoporosis in ovariectomized rats. Eur Spine J. 2014. [OA]
  • Konnecke I, Serra A, El Khassawna T, Schlundt C, Schell H, Hauser A, Ellinghaus A, Volk HD, Radbruch A, Duda GN, Schmidt-Bleek K. T and B cells participate in bone repair by infiltrating the fracture callus in a two-wave fashion. Bone. 2014. [OA]
  • Müller R, Kampschulte M, El Khassawna T, Schlewitz G, Hürter B, Böcker W, Bobeth M, Langheinrich AC, Heiss C, Deutsch A. Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model. Med Biol Eng Comput. 2014.
  • Thormann U*, El Khassawna T*, Ray S, Duerselen L, Kampschulte M, Lips K, von Dewitz H, Heinemann S, Heiss C, Szalay G. Differences of bone healing in metaphyseal defect fractures between osteoporotic and physiological bone in rats. Injury. 2014. (Equal contribution) [OA]
  • Govindarajan P, Böcker W, El Khassawna T, Kampschulte M, Schlewitz G, Huerter B, Sommer U, Dürselen L, Ignatius A, Bauer N, Szalay G, Wenisch S, Lips KS, Schnettler R, Langheinrich A, Heiss C. Bone matrix, cellularity, and structural changes in a rat model with high-turnover osteoporosis induced by combined ovariectomy and a multiple-deficient diet. Am J Pathol. 2014.
  • Kühnisch J, Seto J, Lange C, Schrof S, Stumpp S, Kobus K, Grohmann J, Kossler N, Varga P, Osswald M, Emmerich D, Tinschert S, Thielemann F, Duda G, Seifert W, El Khassawna T, Stevenson DA, Elefteriou F, Kornak U, Raum K, Fratzl P, Mundlos S, Kolanczyk M. Multiscale, converging defects of macro-porosity, microstructure and matrix mineralization impact long bone fragility in NF1. PLoS One. 2014. [OA]

 

2013

  • Govindarajan P, Khassawna T, Kampschulte M, Bocker W, Huerter B, Durselen L, Faulenbach M, Heiss C. Implications of combined ovariectomy and glucocorticoid (dexamethasone) treatment on mineral, microarchitectural, biomechanical and matrix properties of rat bone. Int J Exp Path. 2013.
  • Henss A, Rohnke M, Knaack S, Kleine-Boymann M, Leichtweiss T, Schmitz P, El Khassawna T, Gelinsky M, Heiss C, Janek J. Quantification of calcium content in bone by using ToF-SIMS-a first approach. Biointerphases. 2013.
  • Thormann U, Ray S, Sommer U, El Khassawna T, Rehling T, Hundgeburth M, Henß A, Rohnke M, Janek J, Lips KS. Bone formation induced by strontium modified calcium phosphate cement in critical-size metaphyseal fracture defects in ovariectomized rats. Biomaterials. 2013. [OA]
  • Thormann U, Ray S, Sommer U, El Khassawna T, Heiss C, Schnettler R, Alt V. Biomaterials for enhancement of bone healing in osteoporotic fractures. BioNanoMaterials. 2013.
  • El Khassawna T, Bocker W, Govindarajan P, Schliefke N, Hurter B, Kampschulte M, Schlewitz G, Alt V, Lips KS, Faulenbach M, Mollmann H, Zahner D, Durselen L, Ignatius A, Bauer N, Wenisch S, Langheinrich AC, Schnettler R, Heiss C. Effects of multi-deficiencies-diet on bone parameters of peripheral bone in ovariectomized mature rat. PLoS One. 2013. [OA]
  • Henss A, Rohnke M, El Khassawna T, Govindarajan P, Schlewitz G, Heiss C, Janek J. Applicability of ToF-SIMS for monitoring compositional changes in bone in a long-term animal model. J R Soc Interface. 2013. [OA]
  • Alt V, Thormann U, Ray S, Zahner D, Durselen L, Lips K, El Khassawna T, Heiss C, Riedrich A, Schlewitz G, Ignatius A, Kampschulte M, von Dewitz H, Heinemann S, Schnettler R, Langheinrich A. A new metaphyseal bone defect model in osteoporotic rats to study biomaterials for the enhancement of bone healing in osteoporotic fractures. Acta Biomater. 2013. [OA]
  • Schlewitz G, Govindarajan P, Schliefke N, Alt V, Böcker W, El Khassawna T, Thormann U, Lips KS, Hemdan NY, Zahner D, Schnettler R, Heiss C. Ovarektomie und Kalzium-/Vitamin D2/D3-arme Diät als Osteoporosemodell an der Wirbelsäule von Sprague-Dawley-Ratten. Zeitschrift fur Orthopadie und Unfallchirurgie. 2013;151:14–9.

 

2012

  • El Khassawna T, Toben D, Kolanczyk M, Schmidt-Bleek K, Koennecke I, Schell H, Mundlos S, Duda GN. Deterioration of fracture healing in the mouse model of NF1 long bone dysplasia. Bone. 2012. [OA]

 

2011

  • Toben D, Schroeder I, El Khassawna T, Mehta M, Hoffmann JE, Frisch JT, Schell H, Lienau J, Serra A, Radbruch A, Duda GN. Fracture healing is accelerated in the absence of the adaptive immune system. J Bone Miner Res. 2011.