Hypoxic Pulmonary Vasoconstriction and Oxygen Sensing

Original Research

Wujak, M., C. Veith, C. Y. Wu, T. Wilke, Z. I. Kanbagli, T. Novoyatleva, A. Guenther, W. Seeger, F. Grimminger, N. Sommer, R. T. Schermuly and N. Weissmann. "Adenylate Kinase 4-A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways." Int J Mol Sci (2021). 22(19) DOI: 10.3390/ijms221910371. PMID: 34638712 PMCID: PMC8508902

Strielkov I, Krause NC, Knoepp F, Alebrahimdehkordi N, Pak O, Garcia C, Ghofrani HA, Schermuly RT, Seeger W, Grimminger F, Sommer N, Weissmann N. Cytochrome P450 epoxygenase-derived 5,6-epoxyeicosatrienoic acid relaxes pulmonary arteries in normoxia but promotes sustained pulmonary vasoconstriction in hypoxia. Acta Physiol (Oxf). 2020 Sep;230(1):e13521. doi: 10.1111/apha.13521. Epub 2020 Jun 22. PMID: 32506676.

Sommer N, Alebrahimdehkordi N, Pak O, Knoepp F, Strielkov I, Scheibe S, Dufour E, Andjelković A, Sydykov A, Saraji A, Petrovic A, Quanz K, Hecker M, Kumar M, Wahl J, Kraut S, Seeger W, Schermuly RT, Ghofrani HA, Ramser K, Braun T, Jacobs HT, Weissmann N, Szibor M. Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing. Sci Adv. 2020 Apr 15;6(16):eaba0694. doi: 10.1126/sciadv.aba0694. PMID: 32426457; PMCID: PMC7159913.

Moreno-Domínguez A, Ortega-Sáenz P, Gao L, Colinas O, García-Flores P, Bonilla-Henao V, Aragonés J, Hüttemann M, Grossman LI, Weissmann N, Sommer N, López-Barneo J. Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors. Sci Signal. 2020 Jan 21;13(615):eaay9452. doi: 10.1126/scisignal.aay9452. PMID: 31848220.

Pak O, Scheibe S, Esfandiary A, Gierhardt M, Sydykov A, Logan A, Fysikopoulos A, Veit F, Hecker M, Kroschel F, Quanz K, Erb A, Schäfer K, Fassbinder M, Alebrahimdehkordi N, Ghofrani HA, Schermuly RT, Brandes RP, Seeger W, Murphy MP, Weissmann N, Sommer N. Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension. Eur Respir J. 2018 Feb 1:1701024. doi: 10.1183/13993003.01024-2017. Epub ahead of print. PMID: 29419444.

Sommer N, Hüttemann M, Pak O, Scheibe S, Knoepp F, Sinkler C, Malczyk M, Gierhardt M, Esfandiary A, Kraut S, Jonas F, Veith C, Aras S, Sydykov A, Alebrahimdehkordi N, Giehl K, Hecker M, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Grossman LI, Weissmann N. Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. Circ Res. 2017 Aug 4;121(4):424-438. doi: 10.1161/CIRCRESAHA.116.310482. Epub 2017 Jun 15. PMID: 28620066; PMCID: PMC5544581.

Veith C, Kraut S, Wilhelm J, Sommer N, Quanz K, Seeger W, Brandes RP, Weissmann N, Schröder K. NADPH oxidase 4 is not involved in hypoxia-induced pulmonary hypertension. Pulm Circ. 2016 Sep;6(3):397-400. doi: 10.1086/687756. PMID: 27683617; PMCID: PMC5019094.

Pak O, Bakr AG, Gierhardt M, Albus J, Strielkov I, Kroschel F, Hoeres T, Hecker M, Ghofrani HA, Seeger W, Weissmann N, Sommer N. Effects of carbon monoxide-releasing molecules on pulmonary vasoreactivity in isolated perfused lungs. J Appl Physiol (1985). 2016 Jan 15;120(2):271-81. doi: 10.1152/japplphysiol.00726.2015. Epub 2015 Nov 19. PMID: 26586910.

Ketabchi F, Ghofrani HA, Schermuly RT, Seeger W, Grimminger F, Egemnazarov B, Shid-Moosavi SM, Dehghani GA, Weissmann N, Sommer N. Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction. Respir Res. 2012 Jan 31;13(1):7. doi: 10.1186/1465-9921-13-7. PMID: 22292558; PMCID: PMC3306743.

Sommer N, Pak O, Schörner S, Derfuss T, Krug A, Gnaiger E, Ghofrani HA, Schermuly RT, Huckstorf C, Seeger W, Grimminger F, Weissmann N. Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing. Eur Respir J. 2010 Nov;36(5):1056-66. doi: 10.1183/09031936.00013809. Epub 2010 Jun 1. PMID: 20516051.

Roth M, Rupp M, Hofmann S, Mittal M, Fuchs B, Sommer N, Parajuli N, Quanz K, Schubert D, Dony E, Schermuly RT, Ghofrani HA, Sausbier U, Rutschmann K, Wilhelm S, Seeger W, Ruth P, Grimminger F, Sausbier M, Weissmann N. Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia. Am J Respir Crit Care Med. 2009 Aug 15;180(4):353-64. doi: 10.1164/rccm.200806-848OC. Epub 2009 Jun 4. PMID: 19498059.

Reviews/Editorials/Letters

Gierhardt, M., O. Pak, D. Walmrath, W. Seeger, F. Grimminger, H. A. Ghofrani, N. Weissmann, M. Hecker and N. Sommer. "Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome." Eur Respir Rev (2021). 30(161) DOI: 10.1183/16000617.0059-2021. PMID: 34526314

Hüttemann M, Sommer N, Weissmann N, Grossman LI. Letter by Hüttemann et al Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction". Circ Res. 2019 Sep 27;125(8):e33-e34. doi: 10.1161/CIRCRESAHA.119.315815. Epub 2019 Sep 26. PMID: 31557122; PMCID: PMC6764598.

Strielkov I, Krause NC, Sommer N, Schermuly RT, Ghofrani HA, Grimminger F, Gudermann T, Dietrich A, Weissmann N. Hypoxic pulmonary vasoconstriction in isolated mouse pulmonary arterial vessels. Exp Physiol. 2018 Sep;103(9):1185-1191. doi: 10.1113/EP087117. Epub 2018 Jul 6. PMID: 29917290.

Strielkov I, Pak O, Sommer N, Weissmann N. Recent advances in oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction. J Appl Physiol (1985). 2017 Dec 1;123(6):1647-1656. doi: 10.1152/japplphysiol.00103.2017. Epub 2017 Jul 27. PMID: 28751366.

Grimminger J, Richter M, Tello K, Sommer N, Gall H, Ghofrani HA. Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension. Can Respir J. 2017;2017:8381653. doi: 10.1155/2017/8381653. Epub 2017 Mar 27. PMID: 28522921; PMCID: PMC5385916.

Sommer N, Strielkov I, Pak O, Weissmann N. Oxygen sensing and signal transduction in hypoxic pulmonary vasoconstriction. Eur Respir J. 2016 Jan;47(1):288-303. doi: 10.1183/13993003.00945-2015. Epub 2015 Oct 22. PMID: 26493804.

Malczyk M, Veith C, Schermuly RT, Gudermann T, Dietrich A, Sommer N, Weissmann N, Pak O. NADPH oxidases-do they play a role in TRPC regulation under hypoxia? Pflugers Arch. 2016 Jan;468(1):23-41. doi: 10.1007/s00424-015-1731-3. Epub 2015 Oct 1. PMID: 26424109.

Fuchs B, Sommer N, Dietrich A, Schermuly RT, Ghofrani HA, Grimminger F, Seeger W, Gudermann T, Weissmann N. Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction. Respir Physiol Neurobiol. 2010 Dec 31;174(3):282-91. doi: 10.1016/j.resp.2010.08.013. Epub 2010 Aug 27. PMID: 20801235.

Sommer N, Dietrich A, Schermuly RT, Ghofrani HA, Gudermann T, Schulz R, Seeger W, Grimminger F, Weissmann N. Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms. Eur Respir J. 2008 Dec;32(6):1639-51. doi: 10.1183/09031936.00013908. PMID: 19043010.

Weissmann N, Sommer N, Schermuly RT, Ghofrani HA, Seeger W, Grimminger F. Oxygen sensors in hypoxic pulmonary vasoconstriction. Cardiovasc Res. 2006 Sep 1;71(4):620-9. doi:  10.1016/j.cardiores.2006.04.009. PMID: 16765922.