Pulmonary Hypertension and Right Heart Insufficiency

Original Research

Wujak, M., C. Veith, C. Y. Wu, T. Wilke, Z. I. Kanbagli, T. Novoyatleva, A. Guenther, W. Seeger, F. Grimminger, N. Sommer, R. T. Schermuly and N. Weissmann. "Adenylate Kinase 4-A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways." Int J Mol Sci (2021). 22(19) DOI: 10.3390/ijms221910371. PMID: 34638712 PMCID: PMC8508902

Saraji, A., A. Sydykov, K. Schäfer, C. F. Garcia-Castro, I. Henneke, N. Alebrahimdehkordi, D. Kosanovic, S. Hadzic, A. Guenther, M. Hecker, H. A. Ghofrani, W. Seeger, R. T. Schermuly, N. Weissmann, N. Sommer and O. Pak. "PINK1-mediated Mitophagy Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension." Am J Respir Cell Mol Biol (2021). 65(2): 226-228 DOI: 10.1165/rcmb.2021-0082LE. PMID: 34328407

Gredic, M., C. Y. Wu, S. Hadzic, O. Pak, R. Savai, B. Kojonazarov, S. Doswada, A. Weiss, A. Weigert, A. Guenther, R. P. Brandes, R. T. Schermuly, F. Grimminger, W. Seeger, N. Sommer, S. Kraut and N. Weissmann. "Myeloid cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice." Eur Respir J (2021). DOI: 10.1183/13993003.01153-2021. PMID: 34475225

Sommer N, Alebrahimdehkordi N, Pak O, Knoepp F, Strielkov I, Scheibe S, Dufour E, Andjelković A, Sydykov A, Saraji A, Petrovic A, Quanz K, Hecker M, Kumar M, Wahl J, Kraut S, Seeger W, Schermuly RT, Ghofrani HA, Ramser K, Braun T, Jacobs HT, Weissmann N, Szibor M. Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing. Sci Adv. 2020 Apr 15;6(16):eaba0694. doi: 10.1126/sciadv.aba0694. PMID: 32426457; PMCID: PMC7159913.

Fysikopoulos A, Seimetz M, Hadzic S, Knoepp F, Wu CY, Malkmus K, Wilhelm J, Pichl A, Bednorz M, Tadele Roxlau E, Ghofrani HA, Sommer N, Gierhardt M, Schermuly RT, Seeger W, Grimminger F, Weissmann N, Kraut S. Amelioration of elastase-induced lung emphysema and reversal of pulmonary hypertension by pharmacological iNOS inhibition in mice. Br J Pharmacol. 2020 Mar 22. doi: 10.1111/bph.15057. Epub ahead of print. PMID: 32201936.

Pichl A*, Sommer N*, Bednorz M, Seimetz M, Hadzic S, Kuhnert S, Kraut S, Roxlau ET, Kojonazarov B, Wilhelm J, Gredic M, Gall H, Tello K, Richter MJ, Pak O, Petrovic A, Hecker M, Schermuly RT, Grimminger F, Seeger W, Ghofrani HA, Weissmann N. Riociguat for treatment of pulmonary hypertension in COPD: a translational study. Eur Respir J. 2019 Jun 27;53(6):1802445. doi: 10.1183/13993003.02445-2018. PMID: 30956210. *equal contribution

Esfandiary A, Kutsche HS, Schreckenberg R, Weber M, Pak O, Kojonazarov B, Sydykov A, Hirschhäuser C, Wolf A, Haag D, Hecker M, Fink L, Seeger W, Ghofrani HA, Schermuly RT, Weißmann N, Schulz R, Rohrbach S, Li L, Sommer N*, Schlüter KD*. Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing. Cardiovasc Res. 2019 Jun 1;115(7):1217-1227. doi: 10.1093/cvr/cvz049. PMID: 30850841; PMCID: PMC6529920. *equal contribution.

Pak O, Scheibe S, Esfandiary A, Gierhardt M, Sydykov A, Logan A, Fysikopoulos A, Veit F, Hecker M, Kroschel F, Quanz K, Erb A, Schäfer K, Fassbinder M, Alebrahimdehkordi N, Ghofrani HA, Schermuly RT, Brandes RP, Seeger W, Murphy MP, Weissmann N, Sommer N. Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension. Eur Respir J. 2018 Feb 1:1701024. doi: 10.1183/13993003.01024-2017. Epub ahead of print. PMID: 29419444.

Sommer N, Hüttemann M, Pak O, Scheibe S, Knoepp F, Sinkler C, Malczyk M, Gierhardt M, Esfandiary A, Kraut S, Jonas F, Veith C, Aras S, Sydykov A, Alebrahimdehkordi N, Giehl K, Hecker M, Brandes RP, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT, Grossman LI, Weissmann N. Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. Circ Res. 2017 Aug 4;121(4):424-438. doi: 10.1161/CIRCRESAHA.116.310482. Epub 2017 Jun 15. PMID: 28620066; PMCID: PMC5544581.

Veith C, Kraut S, Wilhelm J, Sommer N, Quanz K, Seeger W, Brandes RP, Weissmann N, Schröder K. NADPH oxidase 4 is not involved in hypoxia-induced pulmonary hypertension. Pulm Circ. 2016 Sep;6(3):397-400. doi: 10.1086/687756. PMID: 27683617; PMCID: PMC5019094.

Veit F, Pak O, Egemnazarov B, Roth M, Kosanovic D, Seimetz M, Sommer N, Ghofrani HA, Seeger W, Grimminger F, Brandes RP, Schermuly RT, Weissmann N. Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling. Antioxid Redox Signal. 2013 Dec 20;19(18):2213-31. doi: 10.1089/ars.2012.4904. Epub 2013 Jul 20. PMID: 23706097.

Pak O*, Sommer N*, Hoeres T, Bakr A, Waisbrod S, Sydykov A, Haag D, Esfandiary A, Kojonazarov B, Veit F, Fuchs B, Weisel FC, Hecker M, Schermuly RT, Grimminger F, Ghofrani HA, Seeger W, Weissmann N. Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model. Am J Respir Cell Mol Biol. 2013 Sep;49(3):358-67. doi: 10.1165/rcmb.2012-0361OC. PMID: 23590303. *equal contribution.

Roth M, Rupp M, Hofmann S, Mittal M, Fuchs B, Sommer N, Parajuli N, Quanz K, Schubert D, Dony E, Schermuly RT, Ghofrani HA, Sausbier U, Rutschmann K, Wilhelm S, Seeger W, Ruth P, Grimminger F, Sausbier M, Weissmann N. Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia. Am J Respir Crit Care Med. 2009 Aug 15;180(4):353-64. doi: 10.1164/rccm.200806-848OC. Epub 2009 Jun 4. PMID: 19498059.

Reviews/Editorials/Letters

Sommer N, Ghofrani HA, Pak O, Bonnet S, Provencher S, Sitbon O, Rosenkranz S, Hoeper MM, Kiely DG. Current and future treatments of pulmonary arterial hypertension. Br J Pharmacol. 2020 Feb 7. doi: 10.1111/bph.15016. Epub ahead of print. PMID: 32034759.

Sommer N. Anoctamin-1: A Novel Mitochondrial Ion Channel Regulating Cellular Apoptosis and Proliferation? Am J Respir Cell Mol Biol. 2018 May;58(5):558-559. doi: 10.1165/rcmb.2017-0355ED. PMID: 29714635.

Grimminger J, Richter M, Tello K, Sommer N, Gall H, Ghofrani HA. Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension. Can Respir J. 2017;2017:8381653. doi: 10.1155/2017/8381653. Epub 2017 Mar 27. PMID: 28522921; PMCID: PMC5385916.

Sommer N, Richter MJ, Tello K, Grimminger F, Seeger W, Ghofrani HA, Gall H. Update pulmonalarterielle Hypertonie: Definitionen, Diagnose, Therapie [Update pulmonary arterial hypertension : Definitions, diagnosis, therapy]. Internist (Berl). 2017 Sep;58(9):937-957. German. doi: 10.1007/s00108-017-0301-5. PMID: 28819824.

Sommer N, Hecker M, Tello K, Richter M, Liebetrau C, Weigand MA, Seeger W, Ghofrani A, Gall H. Pulmonale Hypertonie : Was ist neu in der Therapie? [Pulmonary hypertension : What is new in therapy?]. Anaesthesist. 2016 Aug;65(8):635-52. German. doi: 10.1007/s00101-016-0207-y. PMID: 27492004.