Prof. Dr. rer. nat. Thaqif El Khassawna
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Arbeitsgruppenleiter / Wissenschaftlicher Mitarbeiter Experimentelle Unfallchirurgie 0641/99-30581 |
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After finishing my Masters at the University of Hannover in Moelcular genetics I joined the Julius Wolf institute at the Charite - University of Medicine in Berlin to study bone healing in neurofibromatosis type one animal model. Early 2012, I joined the experimental trauma surgery at the faculty of medicine in Giessen University as a part of the SFB TRR 079 and later further DFG and BMB funded projects. However, to realize my visions and overcome obstacles I recruited an interdisciplinary team of scientists to cover microscopy, molecular biology, chemistry, bioinformatics, and cell biology. In this short period, the team developed histological protocols to accelerate and improve sample preparation and enhance single – sample analysis for light and electron microscopy. We developed semi-automated plugins tailored to our specific histological stains, generated two transgenic rat models and started a core biomechanical laboratory.
Forschungsschwerpunkte:
- Bone healing and tissue regeneration
- Establishment of preclinical models
- Understanding of osteocyte survival and networking
- Fat metabolism in bone diseases
Aktuelle Forschungsprojekte:
- LOEWE-Explorationsprojekt „AutiBone — zelluläre und molekulare Auswirkungen auf das Skelettsystem bei Autismus- Spektrum -Störungen"
Special Issue of International Journal of Molecular Sciences
"Biological Cues for Tissue Regeneration and Bioactive Materials"
Special Issue Guest Editor: Dr. Thaqif El Khassawna
Publikationen von Prof. Dr. El Khassawna ...
Ausgewählte Publikationen:
- El Khassawna T, Merboth F, Bocker W, Malhan D, Daghma DS, Stözel S, Kern S, Hassan F, Rosenbaum D, Langenstein J, Bauer N, Schlagenhauf A, Rösen-wolff A, Schulze F, Rupp M, Hose D, Secklinger A, Ignatius A, Wilke HJ, S. LK, Heiss C. Osteocytes regulation of RANK-LRANKL/OPG in a sheep model of osteoporosis. Am J Path 2017.
- El Khassawna T, Daghma DS, Stözel S, Ray S, Kern S, Malhan D, Alt V, Thromann U, Henss A, Rohnke M, Stengel A, Hassan F, Maenz S, Jandt KD, Diefenbeck M, Schumacher M, Gelinsky M, S. LK, Heiss C. Post-embedding decalcification of mineralized tissue sections preserves the integrity of implanted biomaterials and minimizes number of experimental animals. BioMed Res Int, 2017.
- Daghma DS, Malhan D, Simon P, Stötzel S, Kern S, Hassan S, Lips KS, Heiss C, El Khassawna T. Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine. JBMM 2017.
- El Khassawna T, Serra A, Bucher CH, Petersen A, Schlundt C, Könnecke I, Malhan D, Wendler S, Schell H, Volk H-D, Schmidt-Bleek K, Duda GN: T Lymphocytes Influence the Mineralization Process of Bone. Front Immunol 2017, 8.
- El Khassawna T, Bocker W, Brodsky K, Weisweiler D, Govindarajan P, Kampschulte M, Thormann U, Henss A, Rohnke M, Bauer N, Muller R, Deutsch A, Ignatius A, Durselen L, Langheinrich A, Lips KS, Schnettler R, Heiss C. Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats. Histochem Cell Biol. 2015;144:491-507.