Inhaltspezifische Aktionen

Highlights from PhD Students

Matthias Miosga (PI: Friedhoff)

participated at the Annual Meeting of the RNA Society, May 2021, and is recipient of an RNA Society Poster Award.

Julian Grützner and Timon Spanka (PI: Klug)

published an “NAR breakthrough article” in Nucleic Acids Research:

Grützner J, Billenkamp F, Spanka DT, Rick T, Monzon V, Förstner KU, Klug G.
The small DUF1127 protein CcaF1 from Rhodobacter sphaeroides is an RNA-binding protein involved in sRNA maturation and RNA turnover.
Nucleic Acids Res. 2021 Apr 6;49(6):3003-3019.

Christina Pfafenrot (PI: Bindereif)

filed a patent application on the use of designer antisense-circRNAs to inhibit SARS-CoV-2 proliferation:
Circular nucleic acids and uses thereof for interfering with genome expression and proliferation of coronaviruses

Christina Pfafenrot, Tim Schneider, Christin Müller, John Ziebuhr, and Albrecht Bindereif
EP 20211415.3; December 2020; patent pending.

The results are published in:
Pfafenrot C, Schneider T, Müller C, Hung LH, Schreiner S, Ziebuhr J, Bindereif A.
Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs.
Nucleic Acids Res. 2021 Nov 24:gkab1096.

Dr. Henrik Melior (PI: Evguenieva-Hackenberg)

finished his dissertation on “Multifunctionality of bacterial 5’-UTRs: trans-acting products of transcription attenuation in bacteria” in November 2020 with “summa cum laude”. He received the dissertation award of the University of Giessen (Natural Sciences sector, 2021). His excellent publication list of five papers includes two first-author articles in Nucleic Acids Research:

Melior H, Li S, Madhugiri R, Stötzel M, Azarderakhsh S, Barth-Weber S, Baumgardt K, Ziebuhr J, Evguenieva-Hackenberg E.
Transcription attenuation-derived small RNA rnTrpL regulates tryptophan biosynthesis gene expression in trans.
Nucleic Acids Res. 2019 Jul 9;47(12):6396-6410.

Melior H, Li S, Stötzel M, Maaß S, Schütz R, Azarderakhsh S, Shevkoplias A, Barth-Weber S, Baumgardt K, Ziebuhr J, Förstner KU, Chervontseva Z, Becher D, Evguenieva-Hackenberg E.
Reprograming of sRNA target specificity by the leader peptide peTrpL in response to antibiotic exposure.
Nucleic Acids Res. 2021 Mar 18;49(5):2894-2915.