Project B 5
Modification of cell-cell- and cell-matrix-communication within bone tissue by new materials
Gap junctions and focal adhesions can be influenced by specific properties of materials. Therefore, investigations on material dependent effects influencing expression of the integrin-subunits av and b1 and of connexin 43 and connexin 45 during differentiation to osteoblasts will be performed. Additionally, differentiation to osteoclasts in samples from healthy and osteoporotic donors will be studied in response to the newly generated materials with special regard to podosomes, to podosomal interactions with different integrin subunits, to CD44 and to cx43-mediated cell communication.
| Osteoclasts in vitro |
Stem cell (CD44, Phalloidin) | Stem cells (CD44, Phalloi) |
Principle Investigators (PI)
- Prof. Dr. med. vet. Sabine Wenisch
Institut für Veterinär-Anatomie, -Histologie
und -Embryologie
Justus-Liebig-Universität Gießen
Contact:
Frankfurter Straße 98
35392 Gießen
Telefon: +49 (0)641 / 99 38 111
Fax: +49 (0)641 / 99 38 109
E-Mail: sabine.wenisch@vetmed.uni-giessen.de
- Dr. med. dent. Dr. rer. nat. E. Ada Cavalcanti-Adam
Biophysikalische Chemie
Ruprecht-Karls-Universität Heidelberg
Contact:
Im Neuenheimer Feld 253
69120 Heidelberg
Telefon: +49 (0)6221 / 54 4256
Fax: +49 (0)6221 / 54 4950
E-Mail: ada.cavalcanti-adam@urz.uni-heidelberg.de
Co-Workers
- Dr. Kristina Glenske (veterinary surgeon)
E-Mail: Kristina.Glenske@vetmed.uni-giessen.de
- Eva Tryankowski (veterinary surgeon)
E-Mail: Eva.Tryankowski@vetmed.uni-giessen.de
- Roman Hund (veterinary surgeon)
E-Mail: Roman.Hund@vetmed.uni-giessen.de
- Anne Hild (technical assistant)
E-Mail: Anne.Hild@vetmed.uni-giessen.de
- Elisabeth Schwab (doctoral student)
Telefon: 06221-544256