Project B12 (new)

In project B12, for the first time, molecular changes through materials that have been incorporated in our murine, ovine, as well as the myeloma mouse model will be analyzed using high-throughput screening techniques. For the latter, RNA-sequencing will be performed, which we established for 1ng RNA. For validation purposes, a novel technique is applied using “human” DNA-microarrays for the investigation of e.g. ovine samples, and data will be functionally validated. This allows i) an integrative interpretation of the material-tissue-interaction (M1-M9, B10, T2) and ii)

These data will provide insight into the molecular changes caused by the incorporated materials and complement the histological (project T2) and imaging analyses (projects B8 and B9), as well as the in vitro generated results (projects B1 and B10).

Principle Investigators (PI)
Dr. med. Dipl. Phys. Dirk Hose Laborleiter des Labors für Myelomforschung Medizinische Klinik V Universitätsklinikum Heidelberg und Nationales Centrum für Tumorerkrankungen Heidelberg Contact: Im Neuenheimer Feld 410 69120 Heidelberg Telefon: +49 (0)6221 / 56 39 047 Email: dirk.hose@med.uni-heidelberg.de
Priv.-Doz. Dr. med. Wolfgang Böcker                     Geschäftsführender Oberarzt     Klinik und Poliklinik für Unfallchirurgie Universitätsklinikum Gießen und Marburg GmbH, Standort Gießen Justus-Liebig-Universität Gießen Rudolf-Buchheim-Str. 7 35392 Gießen Telefon: 0641/985-44 601 Email: wolfgang.boecker@chiru.med.uni-giessen.de
Prof. Dr. med. Angela Rösen-Wolff Universitätsklinikum Gustav Carus Klinik und Poliklinik für Kinder- und Jugendmedizin Labor Klinische Forschung Contact: Fetscherstr. 74 01307 Dresden Telefon: +49 - (0)351 - 458 6870 Fax: +49 - (0)351 - 458 6333 Email: Angela.Roesen-wolff@uniklinikum-dresden.de