Project B9
Quantitative studies of metabolism (F-18-deoxyglucose) and bone metabolism (F-18-fluoride) with dynamic positron emission tomography-computed tomography (dPET-CT)
Dynamic PET-CT studies with FDG and fluoride will be performed in patients with multiple myeloma in order to assess active myeloma lesions and the value of the proliferation tracer F-18-FLT will be investigated. Beside the assessment of the response to therapy, this data build the basis for a local treatment using drug-releasing biomaterials in case of persisting resistant lesions after aggressive chemotherapy or if active myeloma lesions in otherwise non-systemic therapy requiring patients exist. Therefore, dPET-CT will be combined with PET-MRI studies. PET-CT studies with FDG and fluoride will also be performed in rats with induced osteoporosis and generated biomaterials will be studied in a rat fracture model to assess bone formation.
| PET study with F-18-Deoxyglucose (FDG). The whole body image demonstrates multiple myeloma lesions with upregulated metabolism, which is indicative for enhanced tumor proliferation. |
Principle Investigators (PI) | |
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KKE Nuklearmedizin, Deutsches Krebsforschungszentrum Contact: Im Neuenheimer Feld 280 69120 Heidelberg Telefon: +49 (0)6221 / 42 - 2500 oder - 2477 Fax: +49 (0)6221 / 42 2476 Email: ads@ads-lgs.com |
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Medizinische Klinik V Universitätsklinikum Heidelberg und Nationales Centrum für Tumorerkrankungen Heidelberg Contact: Im Neuenheimer Feld 410 69120 Heidelberg Telefon: +49 (0)6221 / 56 80 03 Fax: +49 (0)6221 / 56 56 47 Email: hartmut.goldschmidt@med.uni-heidelberg.de |
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Co-Workers
- Dr. Caixia Cheng
Email: c.cheng@Dkfz-Heidelberg.de