Project B7
Influence of aetiology-adapted bone substitutes on the regulation of bone remodeling, microvascularisation and innervation in systemically diseased bone
During the first period of TRR 79 it has been clearly demonstrated that the non-neuronal and neuronal cholinergic system is involved in bone remodeling and connected to the neurotrophin BDNF. The future work will deepen the knowledge of this signal pathway in fracture healing of the systemically diseased bone through conducting of an osteoporotic mouse fracture model with insertion of a BDNF modified bone substation material that will be carefully analyzed in-vitro before implantation. One important focus of the in-vivo investigations in project B7 will be the regulation of lymphangiogenesis as well as microvascularisation.
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Principle Investigators (PI)
- Prof. Dr. rer. nat. Katrin Lips
Labor für Experimentelle Unfallchirurgie
Justus-Liebig-Universität Gießen
Contact:
Kerkrader Str. 9
35394 Gießen
Telefon: +49 (0)641 / 9433117
Fax: +49 (0)641 / 9433119
E-Mail: Katrin.S.Lips@chiru.med.uni-giessen.de
- Prof. Dr. med. Olaf Kilian
Zentralklinik Bad Berka GmbH
Contact:
Robert-Koch-Allee 9
99437 Bad Berka
Telefon: +49 (0)36458-52501
Fax: +49 (0)36458-53538
E-Mail: OUC@zentralklinik-bad-berka.de
Co-Workers
- Dr. Katja Trinkaus
E-Mail: Katja.Trinkaus@chiru.med.uni-giessen.de
- Dipl.-Humanbiol. Vivien Kauschke
E-Mail: Vivien.Kauschke@chiru.med.uni-giessen.de
- Imke Panzer
E-Mail: Imke.Panzer@paediat.med.uni-giessen.de
- Anne Hild
- Iris Schütz