Project M5

The project M5 is divided in two main fields of investigation. First, we are interested in the plasma assisted anodic oxidation of metal implant alloys for improving the biocompatibility of the surface. By using plasmas it is possible to clean, produce a corrosion protection layer and sterilize the sample in one step without toxic chemicals. Furthermore this project focuses on the use of Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) as an analytical tool for the investigation of bone, biomaterial/bone interfaces and cells. Among others we aim to use this technique for drug localisation in bone. 

 Diagram of the time of flight secondary ion mass spectrometry principal  

Primary ions (e.g. Bi₃+clusters) hit the sample surface and initiate a collision cascade. This causes a secondary ion emission from the top most sample surface layers. The ionised particles are collected, separated in the analyser by their flight time and detected. A more intensive C₆₀ ion beam can be used to remove the sample layer by layer. Thus we can get a 3 dimensional mass distribution of a sample area of typically 100 μm x 100 μm x 10 μm.
(Source: Henß A, Rohnke M, Janek J, Heiß C. Labor&more 4.11:2-7)

Bone cross section: a Stained light microscopy image and b ToF-SIMS-mass image of the same sample: The image show the summed up signal intensities of the fragments PO₃–, PO₂–, C₁₆H₃₂O– and C₁₆H₃₀O₃ –: 1= Implant, 2= new formed bone, 3= bone cells, 4= fat vacuole and 5= bone marrow cells
(Source: Henß A, Rohnke M, Janek J, Heiß C. Labor&more 4.11:2-7)

Principle Investigators (PI)
Prof. Dr. rer. nat. Jürgen Janek  Leiter des Teilprojekts M5 Physikalisch-Chemisches Institut Justus-Liebig-Universität Gießen Anschrift: Heinrich-Buff-Ring 58 35392 Gießen Telefon: +49 - (0)641 - 99 34500 Fax: +49 - (0)641 - 99 34509 E-Mail: Juergen.Janek@phys.chemie.uni-giessen.de
Dr. rer. nat. Marcus Rohnke Physikalisch-Chemisches Institut Justus-Liebig-Universität Gießen Anschrift: Heinrich-Buff-Ring 58 35392 Gießen Telefon: +49 - (0)641 - 99 34502 Fax: +49 - (0)641 - 99 34509 E-Mail: Marcus.Rohnke@phys.chemie.uni-giessen.de
Co-Workers
Dr. Anja Henß Postdoc Physikalisch-Chemisches Institut Justus-Liebig-Universität Gießen Anschrift: Heinrich-Buff-Ring 58 35392 Gießen Telefon: +49 - (0)641 - 99 34570 E-Mail: Anja.Henss@phys.chemie.uni-giessen.de
Julia Kokesch-Himmelreich Doctoral Student Physikalisch-Chemisches Institut Justus-Liebig-Universität Gießen Anschrift: Heinrich-Buff-Ring 58 35392 Gießen Telefon: +49 - (0)641 - 99 34515 E-Mail: Julia.Kokesch-Himmelreich@phys.chemie.uni-giessen.de
M.Sc. Markus Göttlicher Doctoral student Physikalisch-Chemisches Institut Justus-Liebig-Universität Gießen Anschrift: Heinrich-Buff-Ring 58 35392 Gießen Telefon: +49 - (0)641 - 99 34546 E-Mail: Markus.Göttlicher@phys.chemie.uni-giessen.de
Katja Schäpe Doctoral Student Physikalisch-Chemisches Institut Justus-Liebig-Universität Gießen Anschrift: Heinrich-Buff-Ring 58 35392 Gießen Telefon: +49 - (0)641 - 99 34515 E-Mail: Kaija.Schaepe@phys.chemie.uni-giessen.de