Project M9 (New)
Functionalized hydrogels presenting simultaneously β1-integrin selective ligands and bone morphogenic protein 6 to stimulate osteoblast function and induce myeloma cell apoptosis
In project M9, functionalized hydrogels will be manufactured and investigated regarding their impact on cellular functions of the interaction of myeloma cells, obsteoblasts, and osteoclasts. Functionalizing will be realized via covalent binding of β1-integrin-selective ligands and bone morphogenic protein 6 (BMP-6) simultaneously. The propagandized effect in vivo is twofold: Osteoblast precursor cells will be attracted from the bone marrow via β1-integrin-selective ligands and stimulated through BMP-6 while osteoclastogenesis is inhibited. In parallel, myeloma cells are attracted and apoptosis is induced through BMP-6 for the purpose of a local control of minimal residual disease.
Principle Investigators (PI)
- Dr. med. dent. Dr. rer. nat. Elisabetta Ada Cavalcanti-Adam
Physikalisch-Chemisches Institut
Biophysikalische Chemie
Ruprecht-Karls-Universität Heidelberg
Contact:
Im Neuenheimer Feld 253
69120 Heidelberg
Telefon: 06221/54-5064
E-Mail: ada.cavalcanti-adam@urz.uni-heidelberg.de
- Dr. med. Anja Seckinger
Universitätsklinikum Heidelberg
Medizinische Klinik V
Sektion Multiples Myelom
Contact:
Im Neuenheimer Feld 410
69120 Heidelberg
Telefon: 06221/56-38497
E-Mail: anja.seckinger@med.uni-heidelberg.de