Project M8

Main research goal in subproject M8 is the mathematical modeling and simulation of the spatio temporal development of the trabecular bone morphology in the presence of bone implants and under the influence of drugs released from implants. This includes the analysis of the impact of the bone cell population dynamics and mechanical load on bone remodeling, the cell migration on scaffold surfaces as well as the promotion of vascularization by drugs. For deeper understanding of the development of the bone morphology in case of multiple myeloma, we will further investigate the interaction between bone cells and malignant plasma cells.

	Finite element calculation of the mechanical loading (relative volume change) of a bone specimen of a human vertebral body as base for the simulation of the bone cell development. Large relative volume changes are labeled red.
	Relative volume change of a loaded osteoporotic iliac-crest bone-specimen. The image reveals locally enhanced deformations of the trabecular bone, which are thought to particularly stimulate the bone growth (dilatation – red, compression – blue).

Principle Investigators (PI)
Prof. Dr. rer. nat. Andreas Deutsch Zentrum für Informationsdienste und Hochleistungsrechnen (ZIH) Technische Universitaet Dresden Contact: Zellescher Weg 12 01069 Dresden Telefon: +49 - (0) 351 463 - 31943 Fax: +49 - (0) 351 463 - 38245 E-Mail: andreas.deutsch@tu-dresden.de
Prof. Dr. rer. nat. habil. Axel Voigt Institut für Wissenschaftliches Rechnen Technische Universität Dresden 01606 Dresden Tel.: 0351/463-34187 E-Mail: axel.voigt@tu-dresden.de
Co-Workers
Dipl.-Phys. Robert Müller Doctoral student Technische Universitaet Dresden Fakultaet Maschinenwesen Institut fuer Werkstoffwissenschaft Lehrstuhl fuer Materialwissenschaft und Nanotechnik Anschrift: Hallwachsstr. 3 01062 Dresden Telefon: +49 - (0) 351 463 - 31406 Fax: +49 - (0) 351 463 - 31422 E-Mail: robert.mueller@tu-dresden.de