September 2017Determination of the mobility of Sr2+ in cortical bone. Within the framework of SFB TRR79, new replacement materials with drug depots are being developed in order to improve fracture healing after an osteoporotic fracture. Those active species are released after implantation over a period as long as possible and to stimulate bone formation locally. Strontium has a dual effect on bone healing: bone-building cells (osteoblasts) are stimulated and bone-degrading cells (osteoclasts) are inhibited. The complete elucidation of the transport of active substances such as Sr2+ in bone can help to predict and simulate the drug mobility in bone and thus reduce animal experiments.a) ToF-SIMS. The upper pictures show the images of Ca2+ (mineralized bone) and Sr2+ signals. In the lower images, the spatial distribution of Ca2+ and Sr2+ in cortical bone is shown in a 3D rendering (depth profile). b) Confocal microscope. Image of the crater in the cortical bone caused by sputtering. (Picture submitted by Christine Kern)https://www.uni-giessen.de/en/faculties/f08/departments/physchem/janek/gallerypotm/pom2017/BdM0917.png/viewhttps://www.uni-giessen.de/@@site-logo/logo.png
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September 2017
Determination of the mobility of Sr2+ in cortical bone. Within the framework of SFB TRR79, new replacement materials with drug depots are being developed in order to improve fracture healing after an osteoporotic fracture. Those active species are released after implantation over a period as long as possible and to stimulate bone formation locally. Strontium has a dual effect on bone healing: bone-building cells (osteoblasts) are stimulated and bone-degrading cells (osteoclasts) are inhibited. The complete elucidation of the transport of active substances such as Sr2+ in bone can help to predict and simulate the drug mobility in bone and thus reduce animal experiments.a) ToF-SIMS. The upper pictures show the images of Ca2+ (mineralized bone) and Sr2+ signals. In the lower images, the spatial distribution of Ca2+ and Sr2+ in cortical bone is shown in a 3D rendering (depth profile). b) Confocal microscope. Image of the crater in the cortical bone caused by sputtering. (Picture submitted by Christine Kern)
